Words similar to villous
Example sentences for: villous
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Figures 5shows that trophoblast cultures from normal placentae, characterized by strong Thy-1 expression in the villous core (panel A), exhibit progressive formation of mid-sized (m) and large syncytial aggregates (l) in early (EC, panel B) and late cultures (LC, panel C).
In normal placentae at term, the LHR immunoreactivity in mature chorionic villi was found in mononucleated cytotrophoblast cells under the syncytial layer (arrowheads, Fig 6A) and villous vascular sinusoids (v), but most of the syncytiotrophoblast was virtually unstained (white asterisks vs. black).
The PT2 can be viewed as placentae with villous and vascular adaptation to imminent placental aging (enhanced villous regeneration and expansion, accompanied by moderate dilatation of villous sinusoids).
Finally, in PT4, Thy-1 expression in terminal villi is very low, but this is not accompanied by dilatation of villous sinusoids.
During the third trimester, and after 34-36 weeks of pregnancy in particular, the placenta may develop an abnormality, often classified as placental aging [ 19 20 21 22 23 24 ] . These abnormal placentae are characterized by generalized interstitial fibrosis and fibrinoid degeneration of villous stroma, and are associated with cellular apoptosis and congestion of villous sinusoids [ 24 25 26 27 ] . Immunohistochemically, villous abnormality is associated with progressive diminution of Thy-1 differentiation protein in the villous core [ 28 ] . Marked changes in villous structure are particularly associated with advanced maternal age [ 29 30 ] . We have recently reported that, with respect to the Thy-1 expression, compensatory dilatation of villous sinusoids, and placental expression of low molecular weight cyclin E variants, the term placentae can be classified into four placental types (PT1-PT4) [ 30 ] , where PT4 corresponds to the most severe placental abnormality.
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