Words similar to villous
Example sentences for: villous
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The former situation might result in placental site trophoblastic tumor or choriocarcinoma [ 28 ] , the latter in the loss of the ability of the villous trophoblast to proliferate.
During the third trimester, and after 34-36 weeks of pregnancy in particular, the placenta may develop an abnormality, often classified as placental aging [ 19 20 21 22 23 24 ] . These abnormal placentae are characterized by generalized interstitial fibrosis and fibrinoid degeneration of villous stroma, and are associated with cellular apoptosis and congestion of villous sinusoids [ 24 25 26 27 ] . Immunohistochemically, villous abnormality is associated with progressive diminution of Thy-1 differentiation protein in the villous core [ 28 ] . Marked changes in villous structure are particularly associated with advanced maternal age [ 29 30 ] . We have recently reported that, with respect to the Thy-1 expression, compensatory dilatation of villous sinusoids, and placental expression of low molecular weight cyclin E variants, the term placentae can be classified into four placental types (PT1-PT4) [ 30 ] , where PT4 corresponds to the most severe placental abnormality.
For statistical purposes in this study, the PT1 (normal) and PT2 placentae (slightly abnormal with compensatory villous differentiation) were coupled as normal placentae (NP).
In contrast, trophoblast cultures from abnormal placentae, which are characterized by weak or no Thy-1 expression in the villous core (panel D), exhibit abortive formation of small (s) syncytial aggregates (panels E and F).
Based on available data [ 29 30 45 50 51 52 ] and our observations, a possible sequence of events involved in asymmetric division of villous CT cells is given in Figure 11A.
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