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Example sentences for: vcip
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Drosophila polarity gene Wunen-2 [ 31 32 ] . PAP2b/VCIP encodes 311 amino acid residues, contains a single N-glycosylation site, a consensus lipid phosphatase motif (KPSXXXRPH), an RGD cell attachment motif, six-transmembrane channel-like structure, and displays Mg ++independent lipid phosphatase activity in transfected 293T cells [ 32 ] . Both N- and C-terminus segments of PAP2b/VCIP are located inside the cytoplasm.
Anti-VCIP/PAP2b-RGD antibody was generated by immunizing rabbit with a synthetic peptide modeled after 20 amino acid residues of VCIP/PAP2b (EGYIQNYRCRGDDSKVQEAR) [ 31 ] .
Consistent with previously published report our data suggest that PAP2b/VCIP is cell surface protein and the expression of VCIP is highly enriched in vascularized tissues.
In addition to its known lipid phosphatase activity, PAP2b/VCIP also mediate cell-cell interactions [ 31 ] .
As a first step towards elucidating the molecular mechanisms and pathways associated with activation of ECs, we cloned the full-length cDNA corresponding to the Clone 33A called VCIP, also known as phosphatidic acid phosphatase type 2b (PAP2b).