Words similar to vaccines
Example sentences for: vaccines
How can you use “vaccines” in a sentence? Here are some example sentences to help you improve your vocabulary:
Preclinical studies assessing the efficacy of potential vaccines, microbicides, or systemic chemoprophylaxis are usually conducted with very high virus challenge doses, which result in infection with certainty.
This is especially relevant to the design of subunit vaccines for malaria and schistosomiasis where high titers of high affinity antibodies are usually the best defence against invading organisms [ 11 16 24 ] . Creating T cell epitopes in expressed proteins has been demonstrated here for Hartley strain guinea pigs, and for various inbred strains of mice [ 37 38 ] . Interestingly, the introduction of T cell epitopes from a hen-egg lysozyme or ovalbumin into mouse TNF-alpha also resulted in an increased cross-reactive antibody response in mice [ 38 ] . However, the protein construct was no longer cytotoxic for L929 cells, suggesting that the modified protein was not in the correct tertiary configuration.
, and partly because this is a fertile area for trying out new techniques, such as DNA vaccines, where there is still a lot to learn.”
The authors have made available the programming script of their analysis so anyone can repeat it; it would be interesting to know whether preclinical trials assessing vaccines or treatments against infections by other pathogens could be usefully modeled in this way as well.
The challenge of utilizing this technique for the creation of subunit vaccines for the human population will be to create T cell epitopes within a protein of interest that will not have deleterious effects on the activity or the stability of the protein of interest, and that would be effective across a number of HLA-DR haplotypes [ 39 ] .
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