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They also prefer the use of highly controlled diagnostic and demographic groups in order to obtain unambiguous answers to isolate the active ingredient of treatment efficacy.
BAGEL analysis allows unambiguous inference as to the expression levels and confidence intervals of these genes of interest.
This is in contrast with the beneficial effects of alcohol intake on CHD among diabetic nurses in the U.S. [ 27 ] , and male British doctors [ 28 ] . An important aspect in the analyzing the effects of alcohol intake is the type of drinks consumed and if they were consumed with meals [ 29 ] . Because alcohol intake data in the FOS cannot make such distinctions, it was perhaps reasonable to expect that the analysis would not provide unambiguous evidence on this issue.
Under those assumptions, there's an unambiguous answer: You should root for Microsoft.
Of the two ways described above in which MHC genotype may affect disease outcome, the first - association between a particular allele and disease outcome - has been repeatedly documented in human populations by various methods of genetic epidemiology [ 17 ] . The second kind of effect, more vigorous immune responses to a pathogen by a heterozygote as compared to homozygotes for the same alleles, which we term "allele-specific overdominance," has been suggested by several animal studies [ 18 19 20 21 ] , although none of these studies is unambiguous (see DISCUSSION).