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Most of these (961) were identified by searching for tri- or tetranucleotide STRs with ≥ 7 or 8 uninterrupted repeats within the sequence assembly available from the University of California - Santa Cruz web site, December 2000 version http://genome.cse.ucsc.edu.
The results were then compared to previous duplication analyses available through the UCSC Genome Browser [ 14 15 16 ] .
1 http://genome.cse.ucsc.edu, no major deletions have been identified except for one report of an exon 60-62 genomic deletion [ 7 ] . Some correlations between FBN1 mutation genotypes and phenotypes are emerging.
In addition, large gap information (> 50 kb) available from the UCSC assembly was incorporated into the same index, where no overlapping information was available between presumably adjacent BACs.
One approach was to use overlapping BAC genomic sequences to select polymorphisms that varied by more than two repeats [ 15 ] . The other approach was to browse the genome for STRs using the December 12, 2000 version of the genomic sequence at University of California - Santa Cruz http://genome.ucsc.edu/ [ 36 ] .