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All above TCs/DTs and sequences associated with Igh-VS107 were mapped to the same locus on chromosome 12 using the UCSC genome browser (data not shown).
Most of these (961) were identified by searching for tri- or tetranucleotide STRs with ≥ 7 or 8 uninterrupted repeats within the sequence assembly available from the University of California - Santa Cruz web site, December 2000 version http://genome.cse.ucsc.edu.
1 http://genome.cse.ucsc.edu, no major deletions have been identified except for one report of an exon 60-62 genomic deletion [ 7 ] . Some correlations between FBN1 mutation genotypes and phenotypes are emerging.
Particular attention was paid to the position of each probe with respect to the three large low-copy repeat clusters found within 15q11-q13; as these clusters contain both inter- and intrachromosomal segmental duplications, and correspond to the common deletion breakpoints of Prader-Willi and Angelman syndrome deletions [ 12 13 21 32 ] . The duplication track of the UCSC Genome Browser, August 2001 assembly, displays information obtained from a global analysis of segmental duplications in the human genome, and allows for the selection of informative unique clones [ 14 16 ] . In this manner, we selected probes flanking the human 15q11-q13 rearrangement breakpoints associated with common PWS/AS deletions.
The results were then compared to previous duplication analyses available through the UCSC Genome Browser [ 14 15 16 ] .