Words similar to tumor-lytic

Example sentences for: tumor-lytic

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In contrast to the differences in RE for G209n peptide, similar assays revealed little difference in RE of the two clones for G209–2M heteroclitic peptide (Figure 4C), suggesting that these clones recognize the native and heteroclitic peptides differently, and that RE for the native, but not heteroclitic, peptide correlates with tumor-lytic potential.
Clones that did not lyse tumor cells required up to 10 3 -fold higher concentration of peptide for similar levels of lysis of targets compared to T cell clones that were tumor-lytic.
We compiled the data on clones from all patients, which showed a correlation between tumor-lytic potential and RE for native peptide (Figure 5A and 5B).
Therefore, optimized use of heteroclitic peptide to induce an initial peptide-specific T cell response, followed by selective expansion of the highest RE tumor-lytic T cells may be needed for an effective strategy with clear clinical application.
Although staining with peptide–MHC tetramers provides a direct estimate for the number of TAA-specific T cells present in vivo, and intensity of tetramer staining has been employed as a parameter for isolation of high-RE, tumor-lytic T cells [27], staining intensity does not correlate well with RE or tumor-lytic potential [28,29], and cannot be considered a reliable indicator for the functional status of TAA-specific T cells.