Words similar to ttp-deficient

Example sentences for: ttp-deficient

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TTP-deficient mice exhibit cachexia, with dermatitis, medullary and extramedullary hyperplasia, erosive polyarthritis, and autoimmunity with autoantibodies [ 25 ] . This phenotype is similar to that observed in mice that overexpress TNF [ 26 ] . In agreement with these data, TTP-deficient mice were shown to overproduce TNF, and weekly injections of a neutralizing antibody to TNF eliminated the predominant features of this phenotype.
The increase in TNF biosynthesis in TTP-deficient mice is associated with increased mRNA stability [ 23 ] . TTP binds to the AU-rich element (ARE) in the 3' untranslated region of TNF mRNA, which regulates TNF mRNA turnover in vivo [ 28 ] . The interaction between TTP/TNF and the ARE promotes the turnover of TNF mRNA.
In addition, mice with the double deletion of TTP and TNF receptor (TNFR)-1 do not manifest the aggressive inflammation observed in TTP-deficient mice.