Words similar to ttp

Example sentences for: ttp

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The addition of LPS rapidly increased the expression of TTP by THP-1 cells (Fig.
A peptide corresponding to the C terminus (amino acids 302-328) of human TTP was synthesized, purified by HPLC, and coupled to KLH (keyhole limpet hemocyanin; Macromolecular Resources, Fort Collins, CO, USA).
Transfection studies using nonhematopoietic cell lines or prolonged cell culture have suggested that TTP is found in both cytoplasm and the nucleus [ 20 21 22 23 24 ] .
The induction of TTP expression by either LPS or TNF has not been studied in an in vivo system before.
The absence of LPS-signal transducers (CD14, Toll-like receptor 4) on most lymphocytes relative to monocytes and neutrophils may account for this altered expression [ 42 43 ] . Since lymphocytes express TNF receptors and TNF itself can induce TTP mRNA expression [ 38 ] , these data are consistent with the interpretation that TTP induction in lymphocytes is transduced not by LPS binding, but by TNF produced by monocytes and/or neutrophils acting on lymphocytes.