Words similar to trypsin-induced
Example sentences for: trypsin-induced
How can you use “trypsin-induced” in a sentence? Here are some example sentences to help you improve your vocabulary:
3mg/ml per week rates of GAG replenishment seen in young bovine cartilage explants recovering from trypsin-induced GAG depletion [ 14 ] . Comparison of these GAG accumulation rates with the rate of GAG release into the culture medium clearly suggests that at least 75% of the newly synthesized GAG is retained by the tissue.
We previously showed that spontaneous recovery from complete trypsin-induced GAG loss occurs uniformly throughout the tissue, showing no significant spatial heterogeneity in recovery rates and nearly complete recovery to the initial state in approximately 5 weeks [ 14 ] . Those data suggest that the capacity for cells to synthesize new matrix is uniform throughout the tissue.
We know from studies investigating the recovery of trypsin-induced homogeneous GAG depletion in young bovine cartilage that the inherent ability of chondrocytes to replenish the matrix is relatively uniform [ 14 ] . In the present study, we take advantage of the characteristic spatial heterogeneity of IL-1-induced GAG depletion to study the relative replenishment rates between regions of varying severity of GAG depletion.
Our group previously observed spatially uniform recovery of explants following trypsin-induced GAG depletion using dGEMRIC, with the increases in [GAG] occurring most rapidly during the first week and slowing considerably after 3 weeks [ 14 ] . Williams et al . [ 15 ] used the same method to monitor GAG accumulation in tissue engineered cartilage over 6 weeks, and observed relatively steady GAG accumulation over the entire period, with the bulk of the accumulation occurring at the periphery of the explant.
The finding that the neurons enter the CNS early in trypsin-treated embryos suggests that continued movement may be a cell autonomous event with trypsin-induced proteolysis generating a permissive environment.
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