Words similar to triggering
Example sentences for: triggering
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While there is extensive crosstalk between the caspases, the two most common initiator pathways are the Fas/Fas ligand pathway, involving caspase 8 and caspase 10, and the mitochondrial pathway, triggering caspase 9 [ 24 25 ] . Caspase 3, a pivotal downstream protease, functions in virtually every caspase pathway and serves as an executioner in the cells by cleavage of downstream targets which lead to irreversible chromosomal degradation.
That mammalian calreticulin is a zinc-dependent protein [ 62] raises the possibility that zinc limitation prevents the proper activity of this protein in yeast, leading to unfolded ER proteins and triggering the subtle increase in expression of genes that participate in the UPR.
To confirm specificity of ceramide in triggering CLENDO cell death, cultures were treated with sphingosine-1-phosphate (S1P; 10 or 50 μM; BioMol; Plymouth Meeting, PA) for 48 h.
The relative gene order in this region is also highly conserved in many bacteria, especially the Gram-positives [ 11 ] . Although intergenic sequences in this region are conserved only among closely related organisms, the DnaA box is found in the non-coding regions flanking dnaA in most bacteria studied [ 12 ] . DnaA boxes are conserved nucleotide sequences (TTGTCCACA) where the DnaA protein binds to DNA, triggering events that ultimately lead to replication initiation and DNA synthesis [ 9 ] .
However, we have argued on the basis of results with ndr1 mutant plants that HR "triggering" in response to the avrRpt2 / RPS2 combination is weaker than that in response to avrB / RPM1 [ 4 ] . Weaker "triggering" results in a lower probability of individual cells undergoing PCD early in the HR, prior to the onset of potentiation caused by increased SA levels [ 4 12 ] . Signaling elicited by avrRpt2 clearly differs in many respects from that directed by the other avr genes.
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