Example sentences for: trec

How can you use “trec” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • IFN = interferon; IL = interleukin; RA = rheumatoid arthritis; RANTES = regulated upon activation, normal T-cell expressed and secreted; SLE = systemic lupus erythematosus; TREC = T-cell receptor excision circle.

  • Although the naïve/memory phenotype of T cells has previously been investigated in RA in numerous studies using CD45RA and CD45RO expression as markers of naïve and memory cells, respectively, that approach has suffered from the limitation that large numbers of CD45RA +CD8 +T cells are actually effector memory cells [ 10 13 ] . The CD45RA/CD45RO oversimplification has also resulted in rather confusing conclusions regarding T-cell homeostasis, such as defects in primary T-cell homeostasis based on reduced T-cell receptor excision circle (TREC) levels in naïve CD4 +T cells (defined as CD45RO -) in RA patients [ 14 ] . Our findings suggest that reduced TREC levels in the CD45RO -CD4 +T-cell population may not be due to a reduction in TRECs in naïve cells but rather to reduced TRECs in the CD45RA +CD45RO -CD62L -effector memory CD4 +T cells.


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