Words similar to transformed
Example sentences for: transformed
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An SV40-transformed BS cell line (GM0855B) was transfected with a plasmid containing an expression unit for the tetracycline or doxycycline (Tet) responsive transcriptional transactivator [ 32].
The latter were previously described in the tumor cell lines K-A31 (Balb/3T3 clone A31 transformed by murine sarcoma virus, [ 32]), and in A875, a malignant human lung melanoma line [ 33].
High levels of OPN in breast tumor cell lines appear to correlate with a more aggressive in vivo phenotype [ 2 20 ] . Transfection of OPN expression constructs into cells producing noninvasive mammary epithelial tumors has been reported to convert them to a malignant phenotype [ 8 21 ] . Furthermore, transfection of antisense OPN constructs or OPN-targeting ribozymes into transformed tumorigenic cells can result in impaired anchorage-independent growth, as well as in diminished tumor-forming ability in vivo [ 22 23 ] . OPN is also typically overexpressed in human tumors, including breast cancer [ 15 24 ] . However, the source of OPN in primary breast tumors was originally thought to be infiltrating macrophages rather than tumor cells themselves [ 15 ] .
But there was nary a ripple of bad news out of Intel when the announcement was made, and the sense of seamlessness that Grove and Barrett have projected has transformed the whole thing into an elegant passing of the torch ceremony.
Tyrosine phosphorylation of Cas is regulated by adhesion, such that adherent and migrating cells have high levels of tyrosine phosphorylated Cas, whereas cells in suspension have reduced levels of Cas phosphorylation [ 10 33 ] . In addition, as mentioned above, transformed cells that are able to grow in an anchorage independent manner show increased tyrosine phosphorylation of Cas [ 10 33 ] . These data suggest that tyrosine phosphorylation of Cas in part regulates a switch from adhesion dependent growth to adhesion independent growth.
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