Words similar to trans-silencer
Example sentences for: trans-silencer
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A translational fusion between green fluorescent protein (GFP) and the Arabidopsis Constitutive Photomorphogenesis1 protein (COP1) has been established as a reporter for trans-silencing events in Arabidopsis [ 27 ] . A cauliflower mosaic virus 35S promoter driven GFP-COP1 locus, named C73, exemplifies an epigenetically active trans-silencer locus.
However, the endogenous p1-rr allele of maize did acquire paramutagenicity after exposure to a specific P1 -enhancer transgene [ 11 ] . Against this background we investigated the possible relay of an imprint triggered by the Arabidopsis C73 trans-silencer locus, asking specifically whether targets trans-silenced by the C73 locus (a) acquired trans-silencing activity, and (b) were able to pass their imprint on to a naive target locus in a heritable fashion.
The C73 trans-silencer locus caused transcriptional silencing of two target loci tested, L91 and E82, which is most easily detected by a suppression of the typical endogene cosuppression of the target loci (Fig.
It is this instability of cosuppression that originally prompted us to categorize certain loci as type C rather than type E. We also characterized the heritability of the imprint imposed by the C73 trans-silencer locus with respect to (a) cosuppression of the COP1 endogene and (b) a characteristic yet unusual expansion of transgene expression at the target locus.
This includes the L72 locus, which has a reduced penetrance of cosuppression that may be attributable to its pericentromeric location [ 27 ] . Intriguingly, both trans-silencer loci, C73 and C97, belong to the 'complex' group, adding weight to the proposition that, like paramutagenicity, trans-silencing activity is encoded epigenetically.
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