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Example sentences for: tox

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Figure 1shows an alignment of the HMG-box region of TOX with HMG-box motifs found in seven other proteins representing the two major subfamilies of HMG-box proteins.
Tox is the murine homologue of the human gene KIAA0808, previously isolated from brain tissue [ 29 ] . TOX and KIAA0808 are approximately 90% identical at both the nucleotide and amino acid level [ 15 ] . Using BLAST program searches [ 30 31 ] we have now identified 3 other murine genes that are predicted to encode proteins that have nearly identical HMG-box sequences to TOX (Fig.
Outside of the HMG-box and NLS, the murine and human homologues of the three additional pairs of proteins are highly conserved, as we reported for TOX and KIAA0808 [ 15 ] . LCP1 and KIAA0737 proteins are approximately 94% identical, while LOC241768 and C20ORF100 share 85% identity.
Based on sequence alignment comparison with other previously characterized HMG-box proteins, we predict that the TOX HMG-box subfamily will likely fall into the sequence-independent category of HMG-box proteins.
The Tox gene has 9 exons spanning more than 300 kb (data not shown).