Example sentences for: tolerizing

How can you use “tolerizing” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In theory, this may result in a situation in which polymorphic self-antigens on one X chromosome may fail to be expressed at sufficiently high levels in a tolerizing compartment, such as the thymus, and yet may be expressed at a considerable frequency in the peripheral soma.

  • It has recently become apparent that mechanisms of peripheral tolerance also exist, and we have considered the possibility that skewed X inactivation in a peripheral tolerizing compartment might also lead to inefficient tolerance.

  • Conceivably, skewed expression of X-linked autoantigens could play a role here, but this would require invoking a peripheral tolerizing compartment that is limiting with respect to the dosage of tolerizing cells to which peripheral T cells can be exposed.

  • In theory, this may result in a situation in which polymorphic self-antigens on one X chromosome may fail to be expressed at sufficiently high levels in a tolerizing compartment, such as the thymus, and yet may be expressed at considerable frequency in the peripheral soma.

  • A major mechanism of peripheral tolerance induction appears to involve the recognition of tolerizing antigens by T cells in the absence of costimulation [ 19].


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