Words similar to tolerized

Example sentences for: tolerized

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Previous studies have shown that adoptively transferred tumor antigen-specific CD4 +T cells can be tolerized in the secondary lymphoid organs [ 9 34 ] , including the RIP-Tag2 model [ 30 ] . Radiation may kill or disable regulatory T cells [ 35 36 ] , or other bone marrow-derived tolerizing cells and prevent the induction of tolerance in adoptively transferred tumor-specific T cells [ 9 ] . Additionally, the high but sub-lethal dose of radiation used leads to significant lymphopenia [ 37 ] . The sudden reduction in lymphocyte number may create the spatial allowance in spleen and lymph nodes necessary for the homing, activation and expansion of he adoptively-transferred T cells.
This may specifically occur in the paracortical regions of lymph nodes, without further progression of the tolerized T cells into lymph node follicles.
This notion has support from studies in tolerized mice: vaccination with a heteroclitic peptide analog recruited T cells, which were responsive to secondary stimulation with native peptide [41,42].
Thus, females may be predisposed to a situation in which they can occasionally express X-linked autoantigens in the periphery to which they have been inefficiently tolerized.