Words similar to tnfβ
Example sentences for: tnfβ
How can you use “tnfβ” in a sentence? Here are some example sentences to help you improve your vocabulary:
Competition ELISAs were performed using TNFα and TNFβ vs. the four phage clones at their ED 50 values (Figure 1a,1b,1c,1d).
No appreciable sequence homology was seen between either of the natural ligands, TNFα or TNFβ, and KcF12 although the spacing of cysteine loop was close to that seen in the cysteine rich domains of TNFR2 [ 29 ] . At present, it is not known whether these structural elements play a role in binding of the peptides to TNFR2 and it may be that the peptides mimic rather than recapitulate the contact domains of the natural ligands.
Therefore, the seven amino acid linker may provide the appropriate molecular distances needed for TNFβ binding to the receptor.
TNFα and TNFβ have been extensively studied and are involved in immune and pro-inflammatory responses, playing an important role in host defenses against infection and other disease states [ 4 5 6 7 ] . The biological effects of TNFα and TNFβ are mediated through the two membrane associated receptors, TNFR1 (p55) and TNFR2 (p75), that are expressed on the target cells [ 8 9 ] . The postulated pathogenic roles for TNF include sepsis and other bacterial and viral pathologies [ 10 11 12 ] , certain cancers [ 13 ] , metastasis [ 14 ] and chronic autoimmune disorders such as rheumatoid arthritis [ 15 16 ] , multiple sclerosis [ 17 ] and Crohn's disease [ 18 ] . It is worth noting that TNFα mutants have been identified that selectively bind TNFR1.
All of the peptides were competed by both TNFα and TNFβ implying they recognized a hotspot that mapped either within or at least overlapping the ligand-binding domain of TNFR2.
Loading...