Words similar to tnfβ
Example sentences for: tnfβ
How can you use “tnfβ” in a sentence? Here are some example sentences to help you improve your vocabulary:
One of these peptides, designated KcB7, had the amino acid sequence RKEMGGGGGPGWSENLFQ . A Blastp search, using several different queries revealed TNFR1, which is the natural biological partner of TNFβ (Figure 5).
More TNFα and TNFβ were required to compete KcF12 than the other phage clones suggesting that certain intrinsic properties of KcF12 (such as its length and/or amino acid content) may contribute to a higher relative affinity (Table 2).
All of the peptides were competed by both TNFα and TNFβ implying they recognized a hotspot that mapped either within or at least overlapping the ligand-binding domain of TNFR2.
TNFα and TNFβ have been extensively studied and are involved in immune and pro-inflammatory responses, playing an important role in host defenses against infection and other disease states [ 4 5 6 7 ] . The biological effects of TNFα and TNFβ are mediated through the two membrane associated receptors, TNFR1 (p55) and TNFR2 (p75), that are expressed on the target cells [ 8 9 ] . The postulated pathogenic roles for TNF include sepsis and other bacterial and viral pathologies [ 10 11 12 ] , certain cancers [ 13 ] , metastasis [ 14 ] and chronic autoimmune disorders such as rheumatoid arthritis [ 15 16 ] , multiple sclerosis [ 17 ] and Crohn's disease [ 18 ] . It is worth noting that TNFα mutants have been identified that selectively bind TNFR1.
The cross reactive phages from the eluted phage were then subtracted by panning sequentially against human TNFR1, TNFα and TNFβ as a way to obtain peptides specific to the original target.
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