Words similar to tnfβ
Example sentences for: tnfβ
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In addition, the synthetic forms of KcC7, KcD11, KcF6 and the recombinant KcF12 (rKcF12) were able to compete the binding of TNFα and TNFβ, as well as KcF6 and KcF12 phage clones in the micromolar range (unpublished data).
One of these peptides, designated KcB7, had the amino acid sequence RKEMGGGGGPGWSENLFQ . A Blastp search, using several different queries revealed TNFR1, which is the natural biological partner of TNFβ (Figure 5).
Therefore, the seven amino acid linker may provide the appropriate molecular distances needed for TNFβ binding to the receptor.
Notably, of the 16 IL-2-induced genes, we had already been identified 4 previously as IL-2 targets using differential colony hybridization (CR3, CR6, CR7, CR8) [ 29 ] , while the 3 other known IL-2 stimulated target genes included TNFβ, the IL-4R, and the anti-apoptotic gene, Bcl2.
All of the peptides were competed by both TNFα and TNFβ implying they recognized a hotspot that mapped either within or at least overlapping the ligand-binding domain of TNFR2.