Words similar to tnfβ
Example sentences for: tnfβ
How can you use “tnfβ” in a sentence? Here are some example sentences to help you improve your vocabulary:
Notably, of the 16 IL-2-induced genes, we had already been identified 4 previously as IL-2 targets using differential colony hybridization (CR3, CR6, CR7, CR8) [ 29 ] , while the 3 other known IL-2 stimulated target genes included TNFβ, the IL-4R, and the anti-apoptotic gene, Bcl2.
TNFα and TNFβ have been extensively studied and are involved in immune and pro-inflammatory responses, playing an important role in host defenses against infection and other disease states [ 4 5 6 7 ] . The biological effects of TNFα and TNFβ are mediated through the two membrane associated receptors, TNFR1 (p55) and TNFR2 (p75), that are expressed on the target cells [ 8 9 ] . The postulated pathogenic roles for TNF include sepsis and other bacterial and viral pathologies [ 10 11 12 ] , certain cancers [ 13 ] , metastasis [ 14 ] and chronic autoimmune disorders such as rheumatoid arthritis [ 15 16 ] , multiple sclerosis [ 17 ] and Crohn's disease [ 18 ] . It is worth noting that TNFα mutants have been identified that selectively bind TNFR1.
In the case of the surrogates for both HCV-mRNA and TNFβ, it is clear that the large diversity and size of the original library was, in fact, critical to their successful isolation since libraries of <20 amino acids would not have contained either the KcB7 peptide or the HCV-specific surrogates.
More TNFα and TNFβ were required to compete KcF12 than the other phage clones suggesting that certain intrinsic properties of KcF12 (such as its length and/or amino acid content) may contribute to a higher relative affinity (Table 2).
One of these peptides, designated KcB7, had the amino acid sequence RKEMGGGGGPGWSENLFQ . A Blastp search, using several different queries revealed TNFR1, which is the natural biological partner of TNFβ (Figure 5).
Loading...