Words similar to thif
Example sentences for: thif
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All 12 sequences in this region have high similarity to the derived consensus sequence GXGXXG(7X)A(SX)GXGXXG(4X)D(9X)R, which defines a nucleotide binding motif [ 16 25 ] . In addition, all sequences have five residues, or conservative substitutions in the case of Pa-MoeB, shown to participate in the adenylation reaction catalyzed by Ec-MoeB (Figure 3) [ 7 ] . The fact that such high similarities are retained in the ThiF coding region across three bacterial divisions suggests that this domain functions more or less autonomously.
MoeB, as represented by the functionally characterized Ec-MoeB, consists of an N-terminal ThiF domain followed by a 2X CXXC domain with both CXXC pairs intact and no rhodanese-like domain.
A similar search using Pa-MoeB as the query yielded 146 sequences with a domain structure similar to MoeB, most of which were entered into the database as MoeB, ThiF, HesA, or ubiquitin-activating enzymes from archaea, bacteria, and eukaryota.
Although they were not included in the analysis presented here, the homologies of Ps-moeZ to sequences in the unfinished microbial genomes of M. avium , M. bovis , and M. smegmatis were also very high and thus provide additional support for the placement of Ps-moeZ in the ThiF tree and suggest that the direction of LGT was from a mycobacterial species to P. stutzeri .
Five of these were eukaryotic sequences of unknown function; five others were eukaryotic MSAE proteins; and one was a ThiF ORF within an operon containing two other thiamin biosynthesis genes in Erwinia amylovora [ 31 ] . The remaining eight sequences were of bacterial origin and were already included in our dataset.
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