Words similar to thermophilus
Example sentences for: thermophilus
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Using the experimentally determined structure as a guide, we split the β and β' subunits of the Thermus thermophilus DDRP and the largest two subunits of the yeast DDRP into individual globular domains and investigated them by visual inspection of the topology, structural searches of the PDB database using the DALI program and iterative searches of the NR database using PSI-BLAST.
The RDRPs of RNA viruses define one major lineage of nucleic acid polymerases, which additionally includes reverse transcriptases, archaeo-eukaryotic DNA polymerases, and nucleotide cyclases [ 8 9 10 11 12 13 ] . The DNA-dependent RNA polymerase of certain bacteriophages, such as T7, and the archaeo-eukaryotic primase (also detected in some bacteria) are divergent derivatives of the same fold [ 11 14 ] . The core catalytic domain of all these enzymes, the so-called "palm" domain, has an RNA-recognition motif (RRM)-like fold with strategically placed metal-coordinating residues, which form the active site [ 11 15 16 ] . In contrast, bacterial DnaG-type primases (also present in archaea and some eukaryotes) contain a polymerase domain of the Rossmann-like TOPRIM fold, which is shared with topoisomerases and OLD-family nucleases [ 17 18 19 ] . The recently solved structures of the DDRPs from yeast and the thermophilic bacterium Thermus thermophilus indicate that the β' subunit (according to the subunit nomenclature of Escherichia coli DDRP, which we hereinafter employ to designate all orthologs of the respective E. coli subunits) of these enzymes defines another distinct catalytic scaffold, which is unrelated to any of the above template-dependent RNA polymerases [ 20 21 22 23 24 ] . Additionally, the structural and evolutionary affinities of two other template-dependent RNA polymerases, namely RDRPs involved in PTGS [ 25 26 27 ] and primases of herpesviruses [ 28 ] , remain obscure.
The poorly characterized phage-or prophage-specific genes that are frequently observed in these neighborhoods include ORF15 ( Streptococcus thermophilus bacteriophage 7201), ORF86, ORF100a ( Staphylococcus aureus temperate phage φSLT) and ORF364 (bacteriophage φ31.
A search of the PDB database using the DALI program [ 61 ] , with this β-barrel from Thermus thermophilus β' subunit submitted as a query (pdb: 1iw7, chain D region: 625-749), retrieved the N-terminal domain of the CDC48-like AAA ATPases, formate dehydrogenases, aspartate decarboxylases and Barwin.
For example, the fusion between COG1788 and COG2057 (α and β subunits of acyl-CoA: acetate CoA transferase) is seen in the bacteria Escherichia coli, Deinococcus radiodurans and Bacillus halodurans , and in the archaea Aeropyrum pernix, Thermophilus acidophilum and Halobacterium sp.
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