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Example sentences for: thdp

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Uptake of ThDP by mitochondria
Interestingly, of the three cell types neuroblastoma cells also are the most resistant to changes in mitochondrial ThDP-utilizing enzyme activity upon progressive depletion of the thiamine made available to the cells [ 6 ] . This suggests that cell-dependent variation in ThDP uptake capacity by mitochondria may contribute to the cell-dependent regulation of ThDP compartmentalization.
A high affinity K m of 0.60 (table 1) was calculated for mitochondrial uptake of ThDP for TRMA lymphoblasts, a value that is essentially the same as that for mitochondria isolated from normal lymphoblasts.
As shown in table 1, high affinity uptake of ThDP by mitochondria from fibroblasts and neuroblastoma cells was essentially the same as that for normal and TRMA lymphoblasts as revealed by the similar K m values.
Within mitochondria, ThDP can be converted to thiamine monophosphate [ 19 ] . Thiamine or ThDP entry into mitochondria from TRMA cells has not been studied.