Words similar to thdp

Example sentences for: thdp

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Interestingly, ThDP-utilizing enzymes in mitochondria are much less affected (as revealed by loss of activity) upon progressive depletion of thiamine available to TRMA cells than are ThDP-utilizing enzymes of the cytosol [ 6 ] . For these reasons, we have examined the uptake of thiamine and especially ThDP by mitochondria from several human cell types, including cells from TRMA patients.
The high affinity K m value compares favorably with the estimated 2 to 3 μM intracellular concentration of free ThDP.
Uptake of thiamine and ThDP by mitochondria
Thiamine entry into mammalian cells occurs by a saturable, high affinity transporter that is deficient in humans with thiamine-responsive megaloblastic anemia (TRMA) [ 7 8 9 10 11 12 ] . Thiamine uptake by mitochondria has been demonstrated [ 13 ] , yet thiamine diphosphokinase is cytosolic and mitochondria cannot convert thiamine to ThDP [ 14 15 16 ] . Barile and coworkers demonstrated saturable uptake of ThDP by rat liver mitochondria characterized by a K m of around 20 μM.
Mitochondria isolated from TRMA lymphoblasts took up ThDP in an essentially identical saturable, biphasic fashion as uptake by normal mitochondria (fig.