Words similar to thdp

Example sentences for: thdp

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The high affinity K m value compares favorably with the estimated 2 to 3 μM intracellular concentration of free ThDP.
Uptake of ThDP by mitochondria
The intracellular concentration of ThDP has been estimated at 30 μM, with only about 7 percent being free cytosolic and the remainder being enzyme-bound with much of this within mitochondria [ 4 5 ] . Previous findings indicate a complex, cell-type dependent regulation of compartmentalization and intracellular pools of thiamine and its phosphorylated derivatives in response to fluctuating extracellular thiamine levels [ 4 5 6 ] . Hence, thiamine transport, including that by mitochondria, is of interest.
The K m values characteristics of the high affinity uptake component (all around 0.4 μM) are comparable to the estimated intracellular concentration of free (non-enzyme bound) cytosolic ThDP of around 3 μM [ 4 ] . This suggests that the high affinity uptake system is the physiologically relevant mechanism responsible for ThDP entry into mitochondria.
Background binding was determined by using a 100 fold excess of unlabelled thiamine or ThDP in parallel reactions.