Words similar to tfiid

Example sentences for: tfiid

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The TATA-box binding protein, a ~30 kDa component of the TFIID complex binds specifically to the heptanucleotide A and T residues [ 1 ] and forms the core of the transcription initiation complex.
The central component of PIC is the general transcription factor (GTF) TFIID, which contains the TATAbox- binding protein (TBP) and 12 to 15 TBP-associated factors (TAFs).
RNA polymerase II (pol II) transcription factor TFIID comprises the TATA-binding protein (TBP) and a set of TBP-associated factors (TAF II s) [ [ 1 2 3 ] ]. At least 12 TAF II s have been identified in TFIID and cloning of their cDNAs has shown an evolutionary conservation of TAF II s from yeast to mammals [ [ 4 5 6 7 ] ]. TAF II s are not only components of the TFIID complex, but a subset of TAF II s are also found in the SAGA, PCAF, TFTC/STAGA complexes which lack TBP [ [ 8 9 10 11 12 ] ].
To determine whether components of basal transcription factor TFIID were subject to regulation during F9 cell differentiation, immunoblotting with monoclonal antibodies against TBP and a number of TAF II s, was used to monitor the levels of the respective proteins in differentiated cell extracts (see Materials and Methods).
Taken altogether, the above results show that the intracellular level of TBP and TAF II 135 and consequently TFIID is significantly reduced in differentiated cells through T-RA-induced proteolytic degradation.