Words similar to tecs

Example sentences for: tecs

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The decrease in DP cells is associated with increased apoptosis in both pre-DP and DP cells [ 29 ] . As the defects at the TN to DP transition in these mutants are caused by defective TEC function rather than thymocyte-intrinsic defects, these mice represent an opportunity to study the role of TECs in promoting this transition.
Using semi-quantitative RT-PCR, we analyzed the expression of two cytokines that are produced by TECs, IL-7 and SCF, in pooled, genotype-matched E14.
Cytokines produced by TECs have been shown to promote proliferation in early stages of thymocyte development, and have been proposed to regulate apoptosis and differentiation, although their precise roles remain controversial [ 23 24 ] . TECs have also been shown to promote thymocyte proliferation in SP cells after selection has occurred [ 15 ] . However, a defined role for TECs at the TN-DP transition remains elusive.
The current study further supports a role for TECs in regulating both thymocyte proliferation and survival during the DN-DP transition, and suggests that proliferation and apoptosis of TN4 and DP cells are regulated independently.
In order to investigate the regulation of thymocyte development by TECs, we are studying Hoxa3 +/- Pax1 -/-compound mutant mice.