Words similar to tecs
Example sentences for: tecs
How can you use “tecs” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cytokines produced by TECs have been shown to promote proliferation in early stages of thymocyte development, and have been proposed to regulate apoptosis and differentiation, although their precise roles remain controversial [ 23 24 ] . TECs have also been shown to promote thymocyte proliferation in SP cells after selection has occurred [ 15 ] . However, a defined role for TECs at the TN-DP transition remains elusive.
Therefore, defects in TECs can in turn cause defects in thymocyte differentiation, proliferation, or cell death.
The current study further supports a role for TECs in regulating both thymocyte proliferation and survival during the DN-DP transition, and suggests that proliferation and apoptosis of TN4 and DP cells are regulated independently.
Hoxa3 and Pax1 are transcription factors that act in a common pathway regulating thymus organogenesis and thymic epithelial cell development [ 29 31 32 33 34 ] . Hoxa3 +/- Pax1 -/-compound mutants have defects in TEC development including reduced numbers of TECs, fewer MHC Class II +TECs, and changes in TEC proliferation and apoptosis.
Our results support a critical role for microenvironment created by TECs in regulating thymocyte proliferation during the TN to DP transition, and show that this function is disrupted in Hoxa3,Pax1 compound mutants.
Loading...