Words similar to tecs
Example sentences for: tecs
How can you use “tecs” in a sentence? Here are some example sentences to help you improve your vocabulary:
The most well defined role for TECs in directly affecting thymocyte differentiation is to mediate positive selection via expression of MHC molecules [ 11 19 20 21 22 ] . However, it is still unclear whether TECs directly promote specific stages of thymocyte differentiation during stages that do not involve MHC-TCR interactions, or whether their role at other stages is primarily to promote cell growth and /or survival.
The decrease in DP cells is associated with increased apoptosis in both pre-DP and DP cells [ 29 ] . As the defects at the TN to DP transition in these mutants are caused by defective TEC function rather than thymocyte-intrinsic defects, these mice represent an opportunity to study the role of TECs in promoting this transition.
Our results support a critical role for microenvironment created by TECs in regulating thymocyte proliferation during the TN to DP transition, and show that this function is disrupted in Hoxa3,Pax1 compound mutants.
In fact, these mutants should have a relative increase in the proportion of TECs, making the reductions seen in cytokine levels in the mutant thymi even more striking.
Cytokines produced by TECs have been shown to promote proliferation in early stages of thymocyte development, and have been proposed to regulate apoptosis and differentiation, although their precise roles remain controversial [ 23 24 ] . TECs have also been shown to promote thymocyte proliferation in SP cells after selection has occurred [ 15 ] . However, a defined role for TECs at the TN-DP transition remains elusive.
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