Words similar to tecs

Example sentences for: tecs

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Cytokines produced by TECs are good candidates for mediating at least some of these changes in thymocyte proliferation and apoptosis in the Hoxa3,Pax1 compound mutants.
5 in the developing thymus, well before significant thymocyte maturation takes place [ 52 53 ] . Although the number of TECs is reduced by about 2-fold in Hoxa3 +/- Pax1 -/-compound mutants, the number of thymocytes is reduced by a slightly greater amount, around 3-fold [ 29 ] . Therefore, the reductions seen in cytokine message levels in the Hoxa3 +/- Pax1 -/-compound mutants are not secondary to decreased TEC numbers.
Hoxa3 and Pax1 are transcription factors that act in a common pathway regulating thymus organogenesis and thymic epithelial cell development [ 29 31 32 33 34 ] . Hoxa3 +/- Pax1 -/-compound mutants have defects in TEC development including reduced numbers of TECs, fewer MHC Class II +TECs, and changes in TEC proliferation and apoptosis.
Taken together, our results further define the role TECs play at this complex stage of thymocyte development.
The decrease in DP cells is associated with increased apoptosis in both pre-DP and DP cells [ 29 ] . As the defects at the TN to DP transition in these mutants are caused by defective TEC function rather than thymocyte-intrinsic defects, these mice represent an opportunity to study the role of TECs in promoting this transition.