Example sentences for: tbz

How can you use “tbz” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In addition, we found that rad3.a , a mutation that disrupts Rad3 kinase activity, confers less TBZ sensitivity than a

  • Since each of the checkpoint rads is an essential component of the checkpoint, TBZ sensitivity can not be the indirect result of defects in the checkpoint response.

  • Mutations that disrupt the microtubule cytoskeleton are also known to sensitize cells to TBZ [ 47 ] . However, using anti-tubulin immunofluorescence, we did not discover any gross microtubule cytoskeletal abnormalities in rad26Δ and rad3Δ cells (data not shown).

  • The TBZ sensitivity assay identifies distinct functions of checkpoint Rad proteins.

  • The kinase activity of Rad3 is essential for checkpoint signaling and is the only known biochemical function of this 220 kDa protein [ 48 49 ] . The rad3.a strain has an amino acid change (D2230A) in the conserved kinase domain of Rad3 that eliminates cell cycle arrest in response to DNA damaging agents [ 48 49 ] . Interestingly, we found that the rad3.a strain is less sensitive to TBZ than the rad3Δ and rad26Δ strains (Figure 4).


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