Words similar to tbz

Example sentences for: tbz

How can you use “tbz” in a sentence? Here are some example sentences to help you improve your vocabulary:

First, the Rad26-GFP dots were resistant to an extraction method that was developed to specifically-preserve the localization of chromatin-binding proteins [ 42 ] . Secondly, we discovered that the rad26Δ strain is sensitive to TBZ, a phenotype common to mutants that disrupt centromeric-heterochromatin [ 45 ] . Finally, fission yeast has a relatively small number of heterochromatic regions (3 centromeres, 6 telomeres, and 1 mating-type locus; [ 53 54 ] ) and the number of Rad26-GFP dots we observe is roughly consistent with localization to these regions.
Since each of the checkpoint rads is an essential component of the checkpoint, TBZ sensitivity can not be the indirect result of defects in the checkpoint response.
Strains carrying the rad26.T12 mutation undergo cell cycle arrest following treatment with a DNA damage agent, but lose viability upon re-entry into the cell cycle [ 13 40 ] . We found that the rad26.T12 strain is significantly less sensitive to TBZ than rad26Δ and rad3Δ (Figure 2).
TBZ sensitivity may reveal a novel role for checkpoint Rad proteins that is independent of the DNA damage checkpoint response.
Mutations that disrupt the microtubule cytoskeleton are also known to sensitize cells to TBZ [ 47 ] . However, using anti-tubulin immunofluorescence, we did not discover any gross microtubule cytoskeletal abnormalities in rad26Δ and rad3Δ cells (data not shown).