Words similar to tbz

Example sentences for: tbz

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Mutations that disrupt the microtubule cytoskeleton are also known to sensitize cells to TBZ [ 47 ] . However, using anti-tubulin immunofluorescence, we did not discover any gross microtubule cytoskeletal abnormalities in rad26Δ and rad3Δ cells (data not shown).
The kinase activity of Rad3 is essential for checkpoint signaling and is the only known biochemical function of this 220 kDa protein [ 48 49 ] . The rad3.a strain has an amino acid change (D2230A) in the conserved kinase domain of Rad3 that eliminates cell cycle arrest in response to DNA damaging agents [ 48 49 ] . Interestingly, we found that the rad3.a strain is less sensitive to TBZ than the rad3Δ and rad26Δ strains (Figure 4).
Since each of the checkpoint rads is an essential component of the checkpoint, TBZ sensitivity can not be the indirect result of defects in the checkpoint response.
As shown, both rad26Δ and rad3Δ cells were sensitive to TBZ (Figure 2).
Next, we tested if the four other checkpoint radΔ alleles ( hus1Δ, rad1Δ, rad9Δ and rad17Δ ) conferred TBZ sensitivity (Figure 3).