Words similar to tat

Example sentences for: tat

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Indeed, in many of these latently infected cells, the induction of NF-κB or the addition of Tat leads to the reactivation of viral replication and spreading of the infection [20,21].
Although Tat was the first activator known that could recruit P-TEFb to initiating RNAPII, additional members of this group were soon identified.
It is interesting to note that Cdc2 (Acc# X05360), Cdc10 homolog (Acc# S72008), and Cdc37 (Acc# U43077) were all up-regulated in Tat expressing cells.
To determine the specificity of Tat action, we used a two Tat deletion mutants (TatΔ31-61 and TatΔ48-56).
Tat has been shown to down-regulate mannose receptor, EDF-1, CD3-gamma, and TCR/CD3 surface receptor [ 14 ] . Tat reduces mannose receptor levels and promoter activity in mature macrophages and dendritic cells by interfering with the host transcriptional machinery; resulting in decreased levels of surface mannose receptor needed for Ag (mannosylated albumin uptake) or pathogen capture (Pneumocystis carinii phagocytosis), and eventual delivery to MHC class II-containing intracellular compartments [ 15 ] . EDF-1, a gene down-regulated when endothelial cells are induced to differentiate in vitro , was shown to be down-regulated by Tat at the transcriptional level, resulting in the inhibition of endothelial cell growth and in the transition from a nonpolar cobblestone phenotype to a polar fibroblast-like phenotype [ 16 ] .