Example sentences for: targeting

How can you use “targeting” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This mutation was previously shown to lower the cytochrome c releasing activity of tBid without affecting its targeting to mitochondria [ 3 ] . Mitochondria treated with tBid G94E displayed better preservation of the outer membrane than those treated with WT tBid.

  • Recently, we demonstrated that the targeting of the pro-apoptotic protein tBid to mitochondria depends upon the presence of the mitochondria-specific lipid cardiolipin in a possibly unique structure [ 9 ] . Cardiolipin has a defined distribution pattern within mitochondria [ 10 ] . It is found in high concentrations throughout the inner membrane, including at contact sites where the inner membrane and outer membrane interact.

  • Once the targeting construct is in hand it takes approximately four to five weeks to generate transgenic mouse embryos.

  • It was subsequently confirmed to be the correct targeting vector by diagnostic PCR, restriction digests and sequencing (data not shown).

  • Isl1-Cre mice were produced by targeting Cre into the Isl1 locus (see Materials and Methods).


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