Words similar to tag-dose

Example sentences for: tag-dose

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, transduction by retrovirus and selection for drug resistance) produces immortal cell lines with limited transformation phenotypes [ 4 5 ] . However, expression of Tag has profound effects on the cell cycle, significantly reducing cell doubling time and increasing saturation density [ 4 5 6 ] . These direct effects of Tag result from binding and inactivation of the retinoblastoma family proteins (p130, Rb, p107) and the tumor suppressor, p53 [ 7 8 9 ] . Tag is rate limiting for G 1 transit, and this effect (as well as saturation density and growth in soft agar) is Tag-dose dependent [ 3 10 11 12 ] . Since the cell lines in this study are capable of entering a quiescent state at saturation density [ 6 ] , one might expect that the levels of Tag would decrease at saturation and as cells progressively slow down as a function of cell density.