Example sentences for: systemically

How can you use “systemically” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Similarly, free viral vectors in solution are administered locally or systemically for in vivo gene transfer applications.

  • While it is likely that these antioxidants are absorbed and exert actions from the vascular space systemically (hence applications in arthritis), knowledge of their pharmacokinetics is limited.

  • Although our results do not preclude the development of gene therapy approaches to express regulated TGF-β1 systemically to downmodulate the immune response, the results suggest that any clinical application of local TGF-β1 gene transfer should proceed with caution.

  • Conversely, IL-10 gene-knockout mice develop a chronic colitis that is extremely similar to IBD [ 25 ] . IL-10 treatment can reduce inflammation in several models of colitis [ 26 27 28 29 30 ] and human IBD [ 31 32 33 34 35 ] . However, the clinical efficacy of systemically administered IL-10 for patients mild to moderately active Crohn's disease has not been as effective as hoped [ 33 34 35 ] . Furthermore the efficacy of IL-10 administration in mouse colitis models is contentious [ 36 ] .

  • IL-4 and IL-10 expression in sera of CIA mice administered Ad-mIL-4 systemically


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