Words similar to systemically
Example sentences for: systemically
How can you use “systemically” in a sentence? Here are some example sentences to help you improve your vocabulary:
The administration of recombinant IL-4 protein systemically has been shown to be therapeutic in murine CIA models if given before onset of disease onset.
In anesthetized rats, doxazosin (alpha 1 adrenergic receptor antagonist) administered systemically, increased micturition volume, bladder capacity, residual volume and micturition frequency while decreasing peak pressure [ 36 ] . Only an increase in the micturition frequency was observed after spinal administration of doxazosin [ 37 ] . Both olanzapine and risperidone have moderate affinity for the alpha 1 adrenergic receptor (Table 1), therefore it is possible that some of the effects observed in the present study were due to central and/or peripheral antagonism of alpha 1 adrenergic receptors by these drugs.
Surprisingly, only top grafting resulted in scions that were systemically silenced by a rootstock signal.
TGF-β1 has been shown to be therapeutic in several different animal models when expressed systemically from muscle tissue [ 26 27 ] . This suggests that elevated serum levels of TGF-β1 can reduce general inflammation as well as inhibit IL-1β and tumor necrosis factor alpha production, resulting in a systemic therapeutic effect.
Conversely, IL-10 gene-knockout mice develop a chronic colitis that is extremely similar to IBD [ 25 ] . IL-10 treatment can reduce inflammation in several models of colitis [ 26 27 28 29 30 ] and human IBD [ 31 32 33 34 35 ] . However, the clinical efficacy of systemically administered IL-10 for patients mild to moderately active Crohn's disease has not been as effective as hoped [ 33 34 35 ] . Furthermore the efficacy of IL-10 administration in mouse colitis models is contentious [ 36 ] .
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