Words similar to systemically

Example sentences for: systemically

How can you use “systemically” in a sentence? Here are some example sentences to help you improve your vocabulary:

Several groups have failed to confirm the initially reported anabolic effect of systemically administered statins in vivo in rats [ 25 26 27 ] . One obvious criticism of the negative data in these studies is that they did not verify the actual presence of statin in the animal serum.
Similarly, free viral vectors in solution are administered locally or systemically for in vivo gene transfer applications.
TGF-β1 has been shown to be therapeutic in several different animal models when expressed systemically from muscle tissue [ 26 27 ] . This suggests that elevated serum levels of TGF-β1 can reduce general inflammation as well as inhibit IL-1β and tumor necrosis factor alpha production, resulting in a systemic therapeutic effect.
Conversely, IL-10 gene-knockout mice develop a chronic colitis that is extremely similar to IBD [ 25 ] . IL-10 treatment can reduce inflammation in several models of colitis [ 26 27 28 29 30 ] and human IBD [ 31 32 33 34 35 ] . However, the clinical efficacy of systemically administered IL-10 for patients mild to moderately active Crohn's disease has not been as effective as hoped [ 33 34 35 ] . Furthermore the efficacy of IL-10 administration in mouse colitis models is contentious [ 36 ] .
The administration of recombinant IL-4 protein systemically has been shown to be therapeutic in murine CIA models if given before onset of disease onset.