Words similar to systemic
Example sentences for: systemic
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The transfer of genes directly to the synovial lining can theoretically circumvent the need for repeat dosing and reduce potential systemic side effects [ 1, 2].
Prostaglandin E 2 is a major cyclooxygenase metabolite of arachidonic acid which exerts diverse effects on vascular smooth muscle tone and epithelial solute transport via G-protein coupled receptors [ 1 2 ] . At least four distinct G-protein coupled PGE 2 receptors have been cloned: the EP 1 , EP 2 , EP 3 , and EP 4 [ 1 ] . Pharmacological studies suggest PGE 2 relaxes vascular smooth muscle through two of these receptors, the EP 2 and EP 4 receptors, which couple to cyclic-AMP generation [ 3 ] . In contrast, PGE 2 constricts other vascular smooth muscle through EP 3 receptors which inhibit cAMP generation via G i or EP 1 receptors which increase Ca 2+mobilization [ 3 ] . Although both EP 2 and EP 4 receptors relax smooth muscle, EP 2 receptors are uniquely sensitive to the agonists butaprost and AH13205 [ 3 4 ] . Previous studies have shown that PGE 2 increases the cAMP concentration in many tissues including kidney, intestine and uterus, but the relative contribution of EP 2 versus EP 4 receptors to these effects is incompletely defined [ 5 6 ] . Recent studies in mice with targeted disruption of these receptors have suggested an important role for EP2 receptor in regulating systemic hemodynamics.
The increase in resistin protein levels correlated with increased resistin gene expression in peripheral blood mononuclear cells following systemic endotoxemia (Figure 5B).
The Wag/Rij rat liver is poorly permissive to the adenoviral infection and accordingly systemic administration of the vector induces low plasma levels of mhATF-BPTI (<80 ng / ml).
In severe systemic inflammation in humans, however, enormous levels of ProCT and other component peptides appear in the serum, while mature serum CT remains normal or only minimally elevated [ 17].
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