Words similar to synthetases
Example sentences for: synthetases
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The Zn-ribbons are widespread, small domains that are comprised of two β-hairpins bounded by consecutive extended regions stabilized by metal-coordinating residues in the hairpin loops [ 67 68 69 70 ] . Zn-ribbons are present in a variety of nucleic-acid-binding proteins, including several ribosomal proteins, translation factors, aminoacyl-tRNA synthetases, RNA polymerase cofactors in archaea and eukaryotes, and several transcription factors.
Permeases, transporters, synthetases and various detoxification enzymes, which, in general, tend to amplify as a response to stressful conditions [ 32, 33, 34, 46, 48, 51], also showed a substantial presence among the recently duplicated genes in all species (see Additional data files).
This potential protein-protein interaction feature of YbaK is additionally supported by evidence that the prolyl-tRNA synthetases (S 1 in Figure 3a) interact with other proteins involved in protein synthesis.
Aminoacyl-tRNA synthetases catalyze a succession of reactions, which involve: hydrolysis of the α-β phosphate bond in ATP; condensation of AMP with the cognate amino acid, resulting in the formation of an aminoacyl-adenylate; displacement of the AMP moiety of the aminoacyl-adenylate with the cognate tRNA, producing aminoacyl-tRNA.
The sequence identity within the HisRS domain of IfkA/B and yeast GCN2 is 28%, with strong conservation within the M1, M2, and M3 motifs that are characteristic of class II aminoacyl-tRNA synthetases [ 37 ] . The similarity between the kinase domains is much higher, with IfkA/B possessing 44% identity with yeast GCN2, with high conservation of all of the kinase subdomains.
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