Words similar to synthetases

Example sentences for: synthetases

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In yeast and mammalian cells, GCN2 is a protein that senses amino acid starvation and brings about altered cell physiology in response to such starvation [ 24 25 ] . GCN2 is a protein kinase that phosphorylates the α subunit of the translation initiation factor eIF2 [ 26 ] . The GCN2 protein from yeasts, Drosophila , and mammals is composed of three domains: a pseudokinase domain that may function as a regulatory domain, a kinase domain, and a HisRS domain that shares significant similarity to histidyl-tRNA synthetases [ 27 28 29 30 ] . Studies of yeast GCN2 revealed that the HisRS domain binds uncharged tRNAs that accumulate when cells are starved for amino acids [ 31 32 ] . As a result the kinase domain is activated and phosphorylates eIF2α at Ser51.
Glutamine synthetases fall into two structurally and functionally distinct classes.
As expected, this list includes several tRNA synthetases, which were previously found to be frequently transferred [ 6 7 8 ] , and enzymes involved in DNA repair ( cf . [ 9 ] ). More surprisingly, this list also includes translation initiation factors and several ribosomal proteins.
The three subclades are YbaK (S 2 in Figure 3a), an insertion domain in the acceptor stem of prokaryotic prolyl-tRNA synthetases (S
In addition, nine orthologs of aminoacyl-tRNA synthetases, and 10 initiation and seven elongation translation factors were detected among trophozoite-specific genes.