Words similar to synthetases
Example sentences for: synthetases
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Aminoacyl-tRNA synthetases (aaRSs) specific for 17 of the 20 amino acids are universally present in cellular life forms.
Many genes that are known to amplify in response to selection, primarily during anticancer drug treatments, were found to be present in multiple copies in mammalian genomes as well, in particular, aminoacyl-tRNA synthetases, glutamine synthetase and other anabolic enzymes, adenosine deaminase, ornithine decarboxylase, AMP deaminase, and N -acetyl glucosaminyltransferase [ 34, 46].
The Zn-ribbons are widespread, small domains that are comprised of two β-hairpins bounded by consecutive extended regions stabilized by metal-coordinating residues in the hairpin loops [ 67 68 69 70 ] . Zn-ribbons are present in a variety of nucleic-acid-binding proteins, including several ribosomal proteins, translation factors, aminoacyl-tRNA synthetases, RNA polymerase cofactors in archaea and eukaryotes, and several transcription factors.
Hence, considerable diversity of protein domains appears to have emerged prior to the "crystallization" [ 95 ] of a transcription machinery similar to the one that operates in modern cells and probably had been already in place in LUCA [ 96 ] . Similar conclusions regarding the early stages of protein domain evolution have been reached previously as a result of evolutionary analysis of proteins involved in translation, such as aminoacyl-tRNA synthetases and GTPases: substantial diversification of protein domains had occurred prior to the "crystallization" of elaborate, modern-type translation machinery [ 66 97 ] .
This potential protein-protein interaction feature of YbaK is additionally supported by evidence that the prolyl-tRNA synthetases (S 1 in Figure 3a) interact with other proteins involved in protein synthesis.