Words similar to synthetases
Example sentences for: synthetases
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Other members of the superfamily include carbamoyl phosphate synthases, cyanophycin synthetases and D-Ala-D-Ala ligases.
The sequence identity within the HisRS domain of IfkA/B and yeast GCN2 is 28%, with strong conservation within the M1, M2, and M3 motifs that are characteristic of class II aminoacyl-tRNA synthetases [ 37 ] . The similarity between the kinase domains is much higher, with IfkA/B possessing 44% identity with yeast GCN2, with high conservation of all of the kinase subdomains.
The three subclades are YbaK (S 2 in Figure 3a), an insertion domain in the acceptor stem of prokaryotic prolyl-tRNA synthetases (S
In the SCOP database, the α-subunit core domains have been classified together with several other domains, including the ligand-binding domain of the bacterial arginine repressor, the dimerization cofactor of the transcription factor HNF1 (DCOH), and a domain specific to the bacterial aspartyl-tRNA synthetases.
The Zn-ribbons are widespread, small domains that are comprised of two β-hairpins bounded by consecutive extended regions stabilized by metal-coordinating residues in the hairpin loops [ 67 68 69 70 ] . Zn-ribbons are present in a variety of nucleic-acid-binding proteins, including several ribosomal proteins, translation factors, aminoacyl-tRNA synthetases, RNA polymerase cofactors in archaea and eukaryotes, and several transcription factors.