Words similar to synapse
Example sentences for: synapse
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This putative association is strengthened by finding for the first time that targeting of RIα requires the AKAP binding surface [ 17 ] . Yotiao is another AKAP enriched at the NMJ, but appears to bind only RII [ 30 ] . PKA phosphorylates the nAChR when stimulated at the synapse by the neuropeptide CGRP and by adenosine from muscle responding to acetylcholine [reviewed by [ 31 ] ]. This phosphorylation may regulate the degradation of the nAChR [ 32 ] . Consistent with the action at the presynapse, it was shown that PKA facilitation of acetylcholine release is dependent on nerve endplate calcium concentration [ 33 ] . Based on our observation of colocalization with synaptophysin at presynaptic vesicles, RIα may be the isotype that influences this release of neurotransmitter.
However, in the presence of the endogenous ligand β-endorphin (when released at the synapse) or another full agonist, a weaker agonist can potentially act as a competitive antagonist.
Significantly, among the five subtypes of muscarinic ACh receptors (MAChRs), Ml and M3 receptors have been shown to efficiently activate PLD (and PKC) in various cell types [ 26 27 28 29 30 ] , whereas activation of PLD by M2 and M4 receptors is less robust [ 26 ] . These observations suggest that in a cholinergic synapse, ACh released into the synaptic cleft might stimulate PLD activity leading to a release of choline that could be used for ACh synthesis.
The parasympathetic innervation arises from preganglionic neurons located in the distal lumbar and proximal sacral spinal cord (segments L6 and S1 in the rat [ 6 7 ] ) and whose axons are found in the pelvic nerve and synapse on postganglionic neurons in the pelvic plexus.
Since dendrites are the primary site of synapse formation, we felt it was important to examine this possibility.
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