Words similar to syk-dependent

Example sentences for: syk-dependent

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The second novel observation, that Syk kinase enzymatic activity was insufficient for signal transduction, suggests that multiple biochemical processes may be required for the Syk-dependent step of signal transduction.
In contrast, BCR-mediated activation of Lyn kinase was largely maintained [ 37 38 ] . The Syk-dependent signaling pathway appears to be facilitated by the adaptor molecule BLNK (also known as SLP-65 and BASH) [ 39 40 41 ] . Syk can induce the phosphorylation of BLNK in co-transfection experiments [ 42 ] , which may be important for the recruitment of other Syk substrates like PLCγ2 through a scaffolding function [ 42 ] . BLNK function is necessary for signal transduction since no Ca 2+flux or PLCγ2 phosphorylation is observed in response to BCR engagement in BLNK-deficient DT40 cells [ 43 ] .
The absence of signaling in the presence of constitutive enzymatic activity described for Syk in different systems implies that execution of the Syk-dependent step in this signaling cascade is a multi-step process.
These data suggest that the Syk-dependent step in signal transduction requires biochemical changes in addition to enzymatic activation, perhaps proper localization of the active enzyme to a signaling receptor complex.