Words similar to syk

Example sentences for: syk

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Thus, despite constitutive Syk activity observed in these infectants, tyrosine phosphorylation did not correlate with activity (compare lanes 7 and 10 of Figure 3Dwith lanes 10 and 7 of Figure 3F).
In summary, here we describe the use of a mutant Syk construct to produce a dominant-positive effect on endogenous Syk activation in the absence of BCR engagement.
By sequestering this negative regulator, expression of the mutant Syk molecules gives rise to the activation of the endogenous wildtype protein in the absence of specific stimulation, leading to a constitutively active Syk phenotype.
No phosphorylated tyrosine residues were detected on Syk in unstimulated or control treated cells (lanes 1,4, and 5).
First, the Y130E mutation resulted in constitutive activity of Syk.