Words similar to syk

Example sentences for: syk

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However, although these cells carry a highly active Syk kinase, no evidence for downstream signaling was found.
Both polyclonal antibody preparations were purified by affinity chromatography on Sepharose-antigen columns [ 27 ] . Immunoprecipitation of Syk protein utilized an affinity purified rabbit anti-Syk antibody (SC-573, Santa Cruz Biotechnology, Santa Cruz, CA, unless otherwise specified).
In contrast, BCR-mediated activation of Lyn kinase was largely maintained [ 37 38 ] . The Syk-dependent signaling pathway appears to be facilitated by the adaptor molecule BLNK (also known as SLP-65 and BASH) [ 39 40 41 ] . Syk can induce the phosphorylation of BLNK in co-transfection experiments [ 42 ] , which may be important for the recruitment of other Syk substrates like PLCγ2 through a scaffolding function [ 42 ] . BLNK function is necessary for signal transduction since no Ca 2+flux or PLCγ2 phosphorylation is observed in response to BCR engagement in BLNK-deficient DT40 cells [ 43 ] .
Expression of a (K395A/3F) mutant Syk results in a dominant positive effect
In syk -deficient DT40 cells, BCR induced apoptosis was abrogated indicating that Syk was necessary for this cellular response [ 38 ] . Having established cells with constitutive Syk activity, it was now possible to establish if Syk activation is sufficient for any of the signaling responses.