Words similar to sw-
Example sentences for: sw-
How can you use “sw-” in a sentence? Here are some example sentences to help you improve your vocabulary:
We have recently reported the role of the inhibitor of NF-κB (IκB) family member Bcl-3 in IL-1-induced MMP-1 expression [ 24 ] . Here we show that overexpression of Bcl-3 can partly abrogate CDDO's inhibitory effects on MMP-1 in SW-1353 cells, suggesting that Bcl-3 might be a target for CDDO.
When these cells were cultured with medium alone, they expressed low levels of MMP-1 and MMP-13, similar to those found in unstimulated SW-1353 cells.
Previously, with the use of Northern blotting, dose-response assays in SW-1353 cells showed that 300 nM was the lowest dose of CDDO sufficient to decrease the IL-1-induced expression of MMP-1 and MMP-13 [ 23 ] . This was confirmed by using quantitative real-time PCR.
Stable SW-1353 cell lines carrying a pBkRSV vector with a Bcl-3 expression insert were created as described previously [ 24 ] . Freshly excised, macroscopically normal cartilage and synovium from OA patients undergoing knee replacement surgery were obtained from a local orthopedic unit (Dartmouth Hitchcock Memorial Hospital, Lebanon, NH, USA).
We have recently described the role of Bcl-3, an IκB family member, in the signaling pathways of IL-1 leading to MMP-1 expression in SW-1353 cells and rabbit synovial fibroblasts [ 24 ] . We found that IL-1 could induce the expression of Bcl-3, and that Bcl-3 had a direct effect on MMP-1 expression through cooperation with NF-κB1/p50.
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