Example sentences for: surrogates

How can you use “surrogates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This non-random association between a surrogate and a target's pharmacologically active site assures a high degree of probability that, once found, surrogates will have utility for the rapid development of SDAs capable of identifying small molecules of pharmacological importance.

  • Thus, the library contained peptide surrogates binding to the HCV target mRNA as well as containing sequence information identifying the natural interacting partner and predicting the putative contact amino acids on the p170 subunit of eIF3.

  • While the expected natural partners were found for many of the proteins, there were instances where surrogates were generated but lacked partner information (e.g.

  • In the case of the surrogates for both HCV-mRNA and TNFβ, it is clear that the large diversity and size of the original library was, in fact, critical to their successful isolation since libraries of <20 amino acids would not have contained either the KcB7 peptide or the HCV-specific surrogates.

  • Finally, it is worthwhile to note that surrogates have been used to develop competitive Site Directed Assays (SDAs) for essential sub-domains thereby allowing their use in high throughput screening of large combinatorial libraries of small molecules (unpublished data).


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