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Example sentences for: suppresses
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ERα enhances AP-1 activity in response to estrogens, [ 28 29 ] but ERβ inhibits AP-1 activity in response to estrogens [ 29 30 31 ] . ERβ also completely suppresses ERα activity at the cyclin D1 promoter and even suppresses the activity of an ERα mutant that is selectively superactive at AP-1 sites and CREs [ 29 ] . Finally, ERβ shows a unique capacity to enhance AP-1 activity in response to selective estrogen receptor modulators (SERMs) such as raloxifene, tamoxifen and ICI 182,780/Faslodex (ICI) [ 30 31 32 ] . Together, these observations suggest that there are fundamental differences in the way that the ERs bind unspecified cofactors that modulate gene expression, and that some of these cofactors must play a role in differential ER activity at AP-1 sites.
Thus, the precise molecular mechanism by which PP5 suppresses the nuclear accumulation of GR remains to be elucidated.
Once IL-10 is produced it functions in an autoregulatory fashion to suppress proinflammatory cytokine mRNA expression and protein production [ 5 6 7 ] . In addition, IL-10 suppresses the expression of MHC class II molecules and costimulatory molecules such as intercellular adhesion molecule 1 and B7, leading to reduction in T-cell macrophage interactions [ 8 9 10 ] .
Accordingly, poly(A) sites are not efficiently recognised when positioned between 5' and 3' splice sites [ 38 39 ] , and insertion of a 5' splice site into a 3' terminal exon suppresses polyadenylation [ 40 42 ] . Conversely, upstream 3' splice sites can enhance polyadenylation [ 43 44 45 ] . We find that the proximal hnRNP A2/B1 exon upstream of the provirus does not lose its identity; rather, the exon splices either to the Neo splice site or to the next hnRNP A2/B1 exon.
Deletion of MIG1or NRG1suppresses mutations in both SNF1and SWI/SNFgenes