Example sentences for: superfamilies

How can you use “superfamilies” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These superfamilies are typified by the formate dehydrogenase C-terminal (FDHC) domain, Barwin endoglucanase, aspartyl protease, and the DPBB domains from the β and β' subunits of DDRP.

  • A variety of environmental small molecules, namely, nutrients, xenobiotics and first messengers are recognized by cells, with the help of specialized protein sensors on their surfaces [ 1 2 ] . Additionally cells also use protein-bound small molecules, such as FAD, cinnamic acid, tetrapyrroles and heme as sensors of photons and the ambient redox states [ 3 4 ] . Within cells, small molecules, such as cyclic nucleotides, are used as intracellular messengers to transduce signals arising from a variety of stimuli [ 1 2 ] . Over the past few years a combination of protein sequence analysis and biochemical studies have revealed several unifying principles that govern the recognition of small molecules by cells [ 4 5 6 7 8 9 ] . A significant component of small molecule-protein interactions is mediated via a relatively small set of ancient conserved protein domains that bind their ligands using specialized pockets [ 4 10 ] . Certain protein folds have given rise to several large superfamilies of ligand-binding domains.

  • The sporadic distribution of this family among phylogenetically distant bacteria, along with its presence in several prophages, suggests that, like the RecT/Redβ and ERF superfamilies, at least the bacterial RAD52-proteins might be of predominantly phage origin.

  • We show that functionally similar SSAPs belong to at least three evolutionarily distinct superfamilies.

  • Sequence comparisons and identification of specific conserved motifs showed that the DPBB fold includes five major superfamilies.


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