Words similar to sulfated
Example sentences for: sulfated
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Engagement of the gp120 coreceptor binding site with a tyrosine sulfated peptide from the N-terminus of the coreceptor CCR5 [ 25 ] , shown to inhibit infection by CCR5-dependent, but not CXCR4-dependent, HIV-1 isolates, was sufficient to increase the expression of the gp41 six-helix bundles in HIV-1 BaL virus particles (Fig.
Interestingly, CAP-gp120 binding also occurs in 1M NaCl, conditions under which binding of sulfated polysaccharides to gp120 is abolished [ 43 ] . This suggests that electrostatic interactions do not play an exclusive role in CAP-gp120 binding [ 51 ] .
The hypothesis that engagement of coreceptor binding sites on gp120 by CAP leads to the expression of gp41 six-helix bundle structures is supported by the finding that a tyrosine sulfated S-peptide, but not the non-sulfated peptide, from the N-terminus of CCR5 [ 25 56 57 ] has an effect similar to that of CAP (Fig.
Negatively charged sulfated polymers were reported to have anti-HIV-1 activity and are being considered for development as topical microbicides.
The retina and malignant solid tumors also produce the sulfated GAGs [ 1 2 22 23 24 25 26 ] . Although HSs are mostly found as proteoglycans associated with the basal lamina or the plasma membrane, the presence of HSs in the culturing medium might be a result of shedding or release of their extracellular domains from the cell membranes as soluble components.