Words similar to substantial

Example sentences for: substantial

How can you use “substantial” in a sentence? Here are some example sentences to help you improve your vocabulary:

This caused an additional supershift, converting a substantial portion of the slower migrating form into a GST-Ned8p modified species (Fig.
The results of the study indicate that, over a 90-day period, survivors of severe sepsis receiving AT III experienced substantial and statistically significant improvements as compared with placebo in several attributes of QoL.
The efficacy of rofecoxib in these five classical clinical analgesic assays is in contrast to two randomized comparisons of rofecoxib with placebo when given before the operation in adults [ 36 ] and children [ 37 ] . The methodological difficulties and lack of effect of preemptive analgesia have been pointed out previously [ 38 39 ] . In these two trials additional difficulties were the large between-individual variation in morphine consumption in adults [ 36 ] , and the use of a novel (unlicensed) syrup formulation of rofecoxib in children [ 37 ] . Lack of a demonstrable analgesic effect in preemptive studies does not negate a substantial postoperative effect when patients both have pain and can swallow.
Journalists, having planned substantial coverage of the 25-year-old Roe case, canceled that date in order to pursue 24-year-old Monica Lewinsky.
The results of the present study suggest that genome trees based on new, integral criteria do not provide substantial advantages in phylogenetic reconstruction over more traditional, alignment-based methods expanded to the genomic scale.