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Example sentences for: stsl
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The intron-exon boundary sequences are indicated in Table 3. In keeping with the human and mouse STSL loci, the rat Abcg5 and Abcg8 genes are arranged in a head-to-head configuration, with a distance of 379 bp separating their respective initiation codons.
To identify if alterations at the STSL locus could account for these observations, we amplified and directly sequenced Abcg5 and Abcg8 from Wistar, Sprague-Dawley, WKY, WKA, GH, SHR, and SHRSP rats.
Interestingly, a cluster of 2 blood pressure (BP) quantitative trait loci (QTL) in (GH × BN) F2 with LOD scores 4.63 (tail BP) and 6.82 (intra-arterial BP) has also been reported to map to rat chromosome 6 between D6Mit3 and D6Mit12 , an area containing the STSL locus.
Recent linkage mapping studies mapped hypertension QTLs to a number of chromosomal regions in SHR and SHRSP rats [ 35 ] . Our FISH study assigned the STSL locus rat chromosome 6q12, a region where a cluster of blood pressure QTL with Lod score 4~6 has been reported to be present (M6MIT12-M6MIT3, 39 cM distance) in a New Zealand genetically hypertensive rat (GH rat) [ 35 ] . With respect to hypertension, although the SHR and SHRSP strains carry the Gly583Cys mutation, in extensive QTL mapping studies using these strains, no loci mapping to the rat STSL region have been reported [ 35 ] . In our study, the GH rat is neither sitosterolemic, nor has any nucleotide alteration at the STSL locus that would implicate this region as mutated.
The rat STSL locus, comprising of Abcg5 and Abcg8 , maps to rat chromosome 6q12, a region syntenic with both mouse and human STSL loci.
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