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Example sentences for: stsl
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Recent linkage mapping studies mapped hypertension QTLs to a number of chromosomal regions in SHR and SHRSP rats [ 35 ] . Our FISH study assigned the STSL locus rat chromosome 6q12, a region where a cluster of blood pressure QTL with Lod score 4~6 has been reported to be present (M6MIT12-M6MIT3, 39 cM distance) in a New Zealand genetically hypertensive rat (GH rat) [ 35 ] . With respect to hypertension, although the SHR and SHRSP strains carry the Gly583Cys mutation, in extensive QTL mapping studies using these strains, no loci mapping to the rat STSL region have been reported [ 35 ] . In our study, the GH rat is neither sitosterolemic, nor has any nucleotide alteration at the STSL locus that would implicate this region as mutated.
The intron-exon boundary sequences are indicated in Table 3. In keeping with the human and mouse STSL loci, the rat Abcg5 and Abcg8 genes are arranged in a head-to-head configuration, with a distance of 379 bp separating their respective initiation codons.
Characterization of the rat STSL locus showed that it is highly conserved in organization, and maps to rat chromosome 6q12, a region also syntenic with the mouse and human STSL loci.
To identify if alterations at the STSL locus could account for these observations, we amplified and directly sequenced Abcg5 and Abcg8 from Wistar, Sprague-Dawley, WKY, WKA, GH, SHR, and SHRSP rats.
To assign the chromosomal location, we performed FISH analyses, and we were able to unambiguously map the rat STSL locus to chromosome 6q12 (Fig.
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