Words similar to structure-based

Example sentences for: structure-based

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In recent years, it has become clear that the neuronal nAChR is a valid target against a variety of diseases, including cognitive and attention deficits, Parkinson's disease, anxiety, and pain management [ 3 4 ] ; the addiction liability and other undesirable side-effects of nicotine prohibit the use of this natural product for therapeutic applications, but the active development of nAChR agonists presenting adequate receptor subtype specificity should result in improved pharmacology and potency [ 4 ] . As for most membrane proteins, information on the 3 dimensional structure of the nAChR is limited, and the best experimental structure consists of 4.6 A data from electron microscopy [ 5 ] , a resolution that does not allow for structure-based design approaches.
Both of these structure-based approaches, used complementarily in conjunction with sequence-only motif-finding approaches [ 56 57 58 ] and experimental data, will enable to us better assign function to all or large parts of a proteome.
Another serious complication in structure-based deduction of function is the intrinsic limit on our ability to compare distantly related sequences and to recognize the role of specific residue subsets in multifunctional proteins.
The resulting models provide a valuable framework for structure-based design of subtype-specific nAChR agonists.
Indeed, structure-based drug design usually derives novel compound structures from ligands previously described.