Words similar to ssz
Example sentences for: ssz
How can you use “ssz” in a sentence? Here are some example sentences to help you improve your vocabulary:
She then developed fatigue, abdominal pain, diarrhea, and night sweats which lead to hospitalization on 8/29/00 and SSZ was discontinued.
Although Still's disease can rarely lead to hepatic involvement with cholestatic hepatitis, the prior history of rheumatoid factor seropositivity and a low serum ferritin level made this diagnosis unlikely [ 21 ] . Granulomatous hepatitis with marked elevations in serum alkaline phosphatase and granulomas on liver biopsy have been reported in patients with SSZ hepatotoxicity [ 22 23 24 ] . Although liver tissue was not obtained in our patient, the predominance of serum alkaline phosphatase and bilirubin level elevations and the presence of granulomas in other tissues suggest that she probably had granulomatous hepatitis.
SSZ has previously been associated with neutropenia with an estimated incidence of 0.04% during the first 30 days of treatment [ 34 ] . Bone marrow biopsy specimens of patients with SSZ induced agranulocytosis reveal a paucity of myeloid cells but full recovery typically occurs within 10 days of drug discontinuation [ 35 36 37 ] . Although our patient had adequate myeloid cells in her bone marrow biopsy, she developed absolute neutropenia by hospital day #19 that improved with steroid therapy.
Seizures have previously been reported in patients receiving SSZ, often in the setting of other clinical manifestations of toxicity [ 31 41 42 ] . Although a brain biopsy would be needed to prove our hypotheses, there is a precedent for other systemic granulomatous disorders such as sarcoidosis leading to CNS granuloma formation and seizures [ 43 44 ] . Fortunately, this patient has remained stable with no evidence of a progressive neurological disorder 7 months after presentation.
Our patient developed a severe systemic illness following three weeks of SSZ therapy for rheumatoid arthritis.
Loading...