Words similar to ssz
Example sentences for: ssz
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Both severe hepatitis and acute liver failure have been attributed to SSZ [ 25 26 27 28 ] . Patients with SSZ hepatotoxicity demonstrate a prompt recurrence of symptoms upon rechallenge with SSZ or sulfonamide [ 15 29 30 31 ] . Susceptibility to the toxic effects of SSZ and other sulfonamides may be due to the interaction of metabolic pathways regulating N-acetylation and specific detoxification of the metabolites of the drug [ 32 33 ] . However, it remains unclear if genetic differences in drug metabolizing enzyme expression may increase the risk of SSZ toxicity.
Three weeks after starting SSZ, the patient developed an erythematous rash over the upper extremities and trunk that improved with cetirizine (Zyrtec, Pfizer Inc, New York, NY).
SSZ has previously been associated with neutropenia with an estimated incidence of 0.04% during the first 30 days of treatment [ 34 ] . Bone marrow biopsy specimens of patients with SSZ induced agranulocytosis reveal a paucity of myeloid cells but full recovery typically occurs within 10 days of drug discontinuation [ 35 36 37 ] . Although our patient had adequate myeloid cells in her bone marrow biopsy, she developed absolute neutropenia by hospital day #19 that improved with steroid therapy.
Fever, rash, and eosinophilia developing within 3 months of initiating SSZ should alert the clinician to the possibility of a drug reaction.
In addition, a possible opportunistic fungal, mycobacterial, or other atypical infection was raised with the high fevers, low grade DIC, and disseminated granulomas that persisted after SSZ discontinuation.
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