Words similar to ssz
Example sentences for: ssz
How can you use “ssz” in a sentence? Here are some example sentences to help you improve your vocabulary:
She then developed fatigue, abdominal pain, diarrhea, and night sweats which lead to hospitalization on 8/29/00 and SSZ was discontinued.
In retrospect, her clinical presentation with rash, fever, and lymphadenopathy within 4 weeks of initiating treatment is consistent with severe SSZ toxicity [ 17 ] . However, in this case and others, it can be difficult to distinguish a severe drug reaction from other disease processes such as infection and malignancy.
Seizures have previously been reported in patients receiving SSZ, often in the setting of other clinical manifestations of toxicity [ 31 41 42 ] . Although a brain biopsy would be needed to prove our hypotheses, there is a precedent for other systemic granulomatous disorders such as sarcoidosis leading to CNS granuloma formation and seizures [ 43 44 ] . Fortunately, this patient has remained stable with no evidence of a progressive neurological disorder 7 months after presentation.
Both severe hepatitis and acute liver failure have been attributed to SSZ [ 25 26 27 28 ] . Patients with SSZ hepatotoxicity demonstrate a prompt recurrence of symptoms upon rechallenge with SSZ or sulfonamide [ 15 29 30 31 ] . Susceptibility to the toxic effects of SSZ and other sulfonamides may be due to the interaction of metabolic pathways regulating N-acetylation and specific detoxification of the metabolites of the drug [ 32 33 ] . However, it remains unclear if genetic differences in drug metabolizing enzyme expression may increase the risk of SSZ toxicity.
Although Still's disease can rarely lead to hepatic involvement with cholestatic hepatitis, the prior history of rheumatoid factor seropositivity and a low serum ferritin level made this diagnosis unlikely [ 21 ] . Granulomatous hepatitis with marked elevations in serum alkaline phosphatase and granulomas on liver biopsy have been reported in patients with SSZ hepatotoxicity [ 22 23 24 ] . Although liver tissue was not obtained in our patient, the predominance of serum alkaline phosphatase and bilirubin level elevations and the presence of granulomas in other tissues suggest that she probably had granulomatous hepatitis.
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