Words similar to ssaps
Example sentences for: ssaps
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Contextual information from gene neighborhoods provides details regarding functional interactions of the SSAPs with DNA recombination pathways
However, no sequence or secondary structural similarities have been noticed between different SSAPs and current understanding of their evolutionary history and phyletic range remains poor.
The clustering of functionally related genes in prokaryotic genomes into co-transcribed and co-regulated units, operons, often allows functional assignments through the principle of 'guilt by association' [ 30 31 32 ] . Generally, genes whose products physically interact to form a complex or are involved in successive steps in a biochemical pathway form operons that are conserved over large evolutionary distances [ 30 ] . On previous occasions, we have used gene neighborhoods or operons to predict novel DNA repair complexes and their components [ 33 ] . Accordingly, a similar approach was applied to the three families of SSAPs (RecT/Redβ, ERF, Rad52), to shed light on their functional links.
Through an analysis of the contextual information provided by the predicted operons, in which the SSAPs occur, we predict several previously undetected functional connections of these proteins, which might shed new light on the corresponding DNA repair/recombination pathways.
It has been suggested in the case of RecT that it may compete with SSB for binding single strand overhangs and thereby make them available for the annealing process [ 3 ] . Similar interactions between other SSAPs and SSB, that probably coats the ssDNA generated by nucleases, appear likely.
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