Example sentences for: sporadic

How can you use “sporadic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Lastly, sporadic individuals with classic CFEOM were screened for ARIX mutations.

  • If real, this sporadic sex difference was not dependent on age, sometimes occurring in a group of B6 mice at a particular age and sometimes not occurring in a separate group of the same age.

  • Mutations in the Hedgehog pathway members PTCH , PTCH 2 , SUFU and Smo , have all been identified in sporadic medulloblastomas as well, with approximately 25% of cases containing mutations affecting these genes [ 5 6 7 8 9 ] . A murine medulloblastoma model was recently developed by disruption of the PTCH gene, with medulloblastoma-like tumors arising in 10-15% of heterozygotes by 9 months of age [ 10 11 ] . Breeding PTCH mice to p53 knockout animals markedly increased tumor incidence.

  • We have previously shown that nuclear β-catenin is present in 18% of sporadic medulloblastomas [ 18 ] .

  • Although there is debate regarding the level of cancer risk associated with mutations in BRCA1 and the significance of the lack of mutations in sporadic tumors, it is possible that alterations in the function of BRCA1 may occur by mechanisms other than mutation.


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