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Example sentences for: solutes

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Figure 1shows the result of applying this technique to experimental data for three different solutes in humans: ethanol [ 24 ] (with or without a meal), standard propranolol [ 26 ] and a long acting form of propranolol [ 26 ] . The squares in these figures describe the time course of the total absorption as determined by PKQuest.
The one exception to the generally good agreement between the PKQuest predictions and the experimental data for these solutes is for the washout of N 2 O (fig.
Since the value of the oil/water partition coefficient varies from 3 for nitrous oxide to 120 for toluene, the ability of PKQuest to model these different solutes using a single set of organ fat fractions (klip) demonstrates the generality of this approach.
In addition, for the two solutes investigated in this paper (D 2 O and ethanol) it is also assumed that the blood-tissue exchange is flow limited so that the unbound water concentration in the tissue is equal to that in the vein leaving the tissue.
The ability of this approach to describe the pharmacokinetics of solutes with an oil/water partition varying from 3 (N 2 O) to 120 (toluene) demonstrates the large range of its validity.