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Example sentences for: sod

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The first proposes that the mutated SOD1 interacts with NO to produce peroxynitrite (ONOO -), which damages proteins by modifying tyrosine to nitrotyrosine residues [ 42 43 44 ] . The second postulates that the mutant SOD1 possesses an enhanced peroxidase activity, which causes oxidative modification of nucleic acids, proteins and lipids [ 45 46 47 ] . Both of these activities require copper at the active center of SOD1.
One study reports that SOD1 aggregation and cell death stimulating activity are dissociable in mutant SOD1-transfected PC12 cells [ 53 ] .
The increased cell death induced by direct targeting of mutant SOD1 to mitochondria supports this possibility [ 27 ] . Interestingly, low levels (compared with the levels caused by mutant SOD1) of mitochondrial vacuolation can also be caused by expression of high levels of wild type SOD1 [ 7 13 15 41 ] , suggesting that the mitochondria-damaging property also exists in the wild type protein and this property strengthens by the mutations.
As summarized in Table 2, two way ANOVA revealed that the activities of SOD, CAT and GPX were not significantly altered in the liver or colon due to the consumption of FOC or of supplemental Vitamin E for two weeks.
It is possible that mitochondrial vacuolation represents an accelerated form of mitochondrial damage caused by high levels of mutant SOD1 accumulation.