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Example sentences for: sn

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Finally, it should be noted that a recent study using cell lines raised the possibility that SN50's action is not specific to NF-κB [ 61 62 ] . SN50 is composed of the NLS for NF-κB p50 and was believed to specifically block NF-κB p50/p65 nuclear translocation by binding the NLS receptor complex and preventing transport through the nuclear pore [ 33 34 35 ] . However, Torgerson and coworkers [ 61 ] have shown that SN50 treatment inhibited nuclear transport of transcription factors NFAT, AP-1, STAT1, and NF-κB at a high dose of 210 μg/ml in Junkrat cells.
Cells were treated with LPS (Sigma), aspirin (Sigma), SN50, and/or control peptide (Biomol, Plymouth Meeting, Pennsylvania, United States), MG132, PD98059, SB20358 (Calbiochem, San Diego, California, United States), and TNFα (R&D Systems, Minneapolis, Minnesota, United States).
SN directed data entry, data cleaning, and preliminary data analyses.
By contrast, NF-κB redistribution was not found in explants cultured in TNF + SN50 (Fig.
12C), PNN analysis shows that members of all three growth factor pathways (Ras/Raf; JAK/STAT; JNK) have high relative importance in discriminating control from SN50-treated explants.