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Example sentences for: sn

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8A), PNN analysis shows that the increased expression of cyclin D2, p57, and Cdc25a, as well as decreased expression of PCNA, best discriminate control from SN50-treated explants.
To determine which key pathways were activated, Western blot analyses of phosphorylated or cleaved proteins in E15+2 CONT and SN50-treated explants were conducted as previously described [ 5 ] . For this set of experiments, we first determined the specificity for each of the following antibodies purchased from Cell Signaling Technology (Beverly, MA) using E15 and E17 SMG homogenates: anti-phosphorylated Erk1/2 [phospho-p44/42 MAP kinase (Thr202/Tyr204)] antibody, anti-phosphorylated c-Raf(Ser259) antibody, anti-cleaved Caspase 3 (D 175) antibody, and anti-cleaved PARP (D214) antibody.
S CN B SN N THS XMPL A A E EE I I EA E
It is reasonable, then, to assume that the high relative importance of diminished GR protein expression to the phenotype of SN50-treated SMGs is directly related to the significant (p < 0.001) decline in cell proliferation and branching (Fig.
E15 SMG primordia were cultured for 2 days in the presence or absence of the cell-permeable peptide SN50, a potent inhibitor of NF-κB nuclear translocation [ 33 34 35 ] . SN50 is composed of a nuclear localization sequence (NLS) for NF-κB p50 linked to a cell-permeable carrier [ 33 34 35 ] . SN50 blocks the intracellular recognition mechanism for the NLS on NF-κB, thus inhibiting NF-κB's translocation through the nuclear pore.