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Example sentences for: sirnas

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Interestingly, perfect or near-perfect target complementarity is associated with mRNA degradation [ 24 25 26 ] , similar to the effects of siRNA, whereas imperfect base-pairing is associated with regulation by translational inhibition [ 6 27 ] . Recently, siRNAs with imperfect match to target mRNA were observed to function as translational inhibitors [ 28 ] , suggesting that the type of 21-22 nucleotide RNA-mediated regulation may be largely determined by the quality of target complementarity.
2002), but not for siRNAs active in RNAi (Finnegan et al.
In positive controls, A549 cell treated with calcium mobilizers (thapsigargin or A23178) did increase eIF-2 phosphorylation, as has been shown earlier [ 30 ] . These results provide the first direct evidence that the 21-nt long double-stranded siRNAs fail to trigger interferon response in mammalian cells, and hence, can be used as specific antiviral agents.
Strikingly, the newly discovered siRNAs were the same size as several ‘small temporal’ RNAs, first identified in 1993 as important regulators of developmental timing in worms (Lee et al.
Once in a cell, a dsRNA molecule is cleaved into segments approximately 22 nucleotides long, called short interfering RNAs (siRNAs) (see Figure 3).