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Example sentences for: sirnas
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In contrast to the ubiquitous DDRP, cellular RDRPs that are involved in PTGS so far have been detected only in eukaryotes [ 1 26 ] . The PTGS phenomenon covers a variety of complementarity-dependent silencing pathways, such as RNA interference (RNAi) in animals and slime mold, co-suppression (silencing of transgene and the corresponding endogenous genes) and virus gene resistance in plants, and quelling in fungi, all of which share a common mechanism of RNA turnover [ 28 37 38 39 40 ] . Essentially, double-stranded (ds) RNA, which is formed in these processes, triggers the activation of a sequence-specific RNA degradation system, which targets homologous RNAs [ 41 42 ] . The dsRNA is broken down by the Dicer enzyme into 21-25 nucleotide (nt) fragments called small interfering RNA or siRNAs [ 43 44 45 ] . The siRNAs subsequently associate with a complex of proteins called RISC and target homologous RNA by serving as guides for multiple rounds of RNA cleavage [ 45 46 ] .
systems demonstrated that 21–23 nucleotide ‘short interfering'RNAs (siRNAs), derived from cutting longer dsRNA, can guide mRNA cleavage (Zamore et al.
Strikingly, the newly discovered siRNAs were the same size as several ‘small temporal’ RNAs, first identified in 1993 as important regulators of developmental timing in worms (Lee et al.
In positive controls, A549 cell treated with calcium mobilizers (thapsigargin or A23178) did increase eIF-2 phosphorylation, as has been shown earlier [ 30 ] . These results provide the first direct evidence that the 21-nt long double-stranded siRNAs fail to trigger interferon response in mammalian cells, and hence, can be used as specific antiviral agents.
2002), but not for siRNAs active in RNAi (Finnegan et al.
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