Words similar to sirna

Example sentences for: sirna

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Interestingly, perfect or near-perfect target complementarity is associated with mRNA degradation [ 24 25 26 ] , similar to the effects of siRNA, whereas imperfect base-pairing is associated with regulation by translational inhibition [ 6 27 ] . Recently, siRNAs with imperfect match to target mRNA were observed to function as translational inhibitors [ 28 ] , suggesting that the type of 21-22 nucleotide RNA-mediated regulation may be largely determined by the quality of target complementarity.
Interestingly, because of the potency of siRNA in some organisms, it has been proposed that they may be replicated by a cellular RdRP activity, although this has been debated [ 4 ] . Furthermore, since dsRNA is known to be a potent inducer of the interferon pathway [ 5 6 ] , it is important to know whether this also occurs in cells in which antisense dsRNA has been introduced.
The anti-profilin double-stranded RNA (siRNA) of the following sequence were made by Dharmacon http://www.dharmacon.com:
Longer pre-treatment with siRNA prior to the addition of the virus did not lead to further reduction of progeny yield, suggesting that 10 hr of siRNA-treatment was sufficient to achieve maximal reduction.
In the very first experiment of this series, we sought to optimize the amount of siRNA, and tested their effects on profilin and viral P protein in infected A549 cells.