Words similar to signal-regulated
Example sentences for: signal-regulated
How can you use “signal-regulated” in a sentence? Here are some example sentences to help you improve your vocabulary:
Involvement of the mitogen-activated protein kinase (MAPK) pathway, extracellular signal-regulated protein kinase (ERK)-1/2 (p44/p42), in cytokine regulation has been demonstrated in HBEs exposed to diesel exhaust particles [ 7 ] but not to cigarette smoke.
However, the signal transduction pathway, MAPK, has been shown to control and be upstream of DNA-replication, transcription, and cell cycle pathways [ 52 53 54 ] . The mitogen-activated protein kinase (MAPK) pathway, consisting of the MAP kinase kinases (MKKs) 1 and 2, and extracellular signal-regulated kinases (ERKs) 1 and 2, which have been implicated in diverse cellular processes including proliferation, transformation, and cell differentiation [ 53 ] . The MAP kinase (MAPK) pathway has emerged as a crucial route between membrane-bound Ras and the nucleus.
Cellular response to chronic TLK286 exposure included a two-fold decrease in GSTP1-1 protein levels, confirming a GSTP1-1 mediated mechanism of activation [ 7 ] . Mouse embryo fibroblast cells from GSTP1-1 deficient animals elevated the expression of signal-regulated kinases ERK1/ERK2 and reduced the doubling time of cell proliferation [ 8 ] . That paper also found that a clone of HL60 cells resistant to TLK199, an inhibitor of GSTP1-1, has been shown to have elevated activities of c-Jun NH 2 -terminal kinase (JNK) and ERK1/ERK2.
Immunoblotting of membranes for phospho-MAPK (extracellular signal-regulated kinase [Erk]1/2) was performed using a Phospho-MAPK Antibody Sampler kit (Cell Signaling, Beverly, MA, USA) according to the manufacturer's instructions.
TGF-β family proteins, including β1,β2 and β3, induce TNF-resistance and suppress the PH-20 effect of increasing TNF cytotoxicity in murine L929 fibroblasts [ 8 11 ] . TGF-β1 induces a novel extracellular matrix protein that prevents TNF-mediated cell death and blocks the activation of extracellular signal-regulated kinase (ERK; also known as p42/44 mitogen-activated protein kinase, p42/44 MAPK) in L929 cells [ 8 12 ] . Additionally, TGF-β1 induces the expression of TIAF1 (TGF-β-induced antiapoptotic factor) [ 13 ] and TIF2 (TGF-β-induced factor 2) [ 14 ] that inhibit TNF cytotoxicity.
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