Words similar to side-effects
Example sentences for: side-effects
How can you use “side-effects” in a sentence? Here are some example sentences to help you improve your vocabulary:
Evidence for cardiotoxicity, as observed in this study, was not expected as supplementation with vitamin E at extremely high doses gave no significant indications of harmful side-effects in animals or in humans [ 18 25 ] . Perhaps vitamin E supplementation acts to inhibit lipid peroxidation but at the same time acts to down regulate other protective antioxidant systems as suggested by the antioxidant enzyme gene expression data in Table 4. If gene expression levels in Table 4reflect antioxidant enzyme activity, then an increase in SOD and decrease in GPX without an increase in CAT would result in accumulation of inorganic and organic peroxides and hydroperoxides that can react with Fe 2+to yield highly reactive free radical products that can damage cellular proteins and DNA as well as lipids.
Because high doses of MG induce vomiting, oedema, dizziness and androgen-like side-effects, the ideal effective concentration is difficult to obtain in vivo . Therefore, the search for new drugs with low toxicity is in progress to meet an urgent need for clinical applications.
Within the MMP family, MMP-1 (collagenase-1) and MMP-13 (collagenase-3) are expressed in arthritic joints, and efficiently degrade type II collagen [ 9 ] . MMP-13 is more effective than MMP-1 in cleaving type II collagen, but it is debated which is the principal collagenase in vivo [ 10 11 ] . These enzymes have been implicated in the pathology of rheumatoid arthritis (RA) and osteoarthritis (OA), and have long been therapeutic targets [ 12 ] . Historically, inhibition of MMP-active sites has been a strategy; however, with wide-ranging side-effects and lack of efficacy, these studies are proving unfruitful in providing an effective drug [ 13 ] .
The Wall Street Journal notes that this week's recall of a major heart drug, Posicor, and the disclosure of another ten deaths of men taking Viagra, are reminders that "While pharmaceuticals manufacturers test their concoctions on several thousand subjects to monitor side-effects and efficacy, the real experiment begins only after a drug hits the market and vastly more people begin taking it."
Histological cross-sections of the heart taken one-third of the distance from the apex were studied for indications of side-effects of high dietary levels of sE.
Loading...