Words similar to side-effects
Example sentences for: side-effects
How can you use “side-effects” in a sentence? Here are some example sentences to help you improve your vocabulary:
My husband says that one of the side-effects of this lower crime rate is that police are arresting fewer people because so many criminals are already locked up.
Within the MMP family, MMP-1 (collagenase-1) and MMP-13 (collagenase-3) are expressed in arthritic joints, and efficiently degrade type II collagen [ 9 ] . MMP-13 is more effective than MMP-1 in cleaving type II collagen, but it is debated which is the principal collagenase in vivo [ 10 11 ] . These enzymes have been implicated in the pathology of rheumatoid arthritis (RA) and osteoarthritis (OA), and have long been therapeutic targets [ 12 ] . Historically, inhibition of MMP-active sites has been a strategy; however, with wide-ranging side-effects and lack of efficacy, these studies are proving unfruitful in providing an effective drug [ 13 ] .
Although the etiologies and pathologies of RA and OA differ, it is clear that in both of these diseases pro-inflammatory cytokines are present, resulting in an inflammatory state as well as cartilage degradation [ 14 ] . As further evidence for the role of pro-inflammatory cytokines in RA, anti-tumor necrosis factor-α (anti-TNF-α) and anti-interleukin 1 (anti-IL-1) therapies can reduce inflammation and retard the progression of disease as assessed radiographically [ 15 16 ] . However, side-effects with these approaches, such as the development of lymphomas in patients using anti-TNF-α therapies, demonstrate that alternative therapies are needed [ 17 ] .
Escalating doses of sedatives followed by oppressive hemodynamic and ventilatory side-effects sometimes provide an indication for therapeutic musculoskeletal paralysis to rapidly get control of life threatening agitation syndromes.
Because high doses of MG induce vomiting, oedema, dizziness and androgen-like side-effects, the ideal effective concentration is difficult to obtain in vivo . Therefore, the search for new drugs with low toxicity is in progress to meet an urgent need for clinical applications.
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